Compositions comprising thienopyrimidine and thienopyridine compounds and methods of use thereof

A compound of Formula 4b:

• or a pharmaceutically acceptable salt thereof, wherein
• each of R1, R7, R3, R4, R5, R6, R7, and R is independently H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, alkene, alkyne, heteroalkyl, alcohol, diol, substituted diol, ether, amine, alkylamine, thiol, thioalkyl, halogen, carbocyclic ring, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl, aldehyde;
• ketone, CO—(CH2)1-6—H, CO-ethenyl, CO-propenyl, CO-ethynyl, CO-propynyl, CO—(CH2)1-6-aryl, CO—(CH2)1-6-heteroaryl, CO—(CH2)1-3-trifluoromethane, CO—(CH2)1-6-cycloalkane, carboxylic acid, alkylcarboxylic acid, ester, alkylester, amide, CO-amino-dialkyl, alkylamide;
• sulfoxide, sulfone, SO2—(CH2)1-6—H, SO2-alkenyl, SO2-alkynyl, SO2NH2, SO2—NH-alkyl, SO2-amino-dialkyl, sulfinic acid, cyano, alkylcyano, methylcarbonitrile, cyanate, thiocyanate, azide, or phosphate;
• wherein R6 is present at one or more positions of the indole;
• Y is N, C—H, or
• Ra is alkyl, substituted alkyl, Amy, cycloalkyl, heteroalkyl, alkyl-substituted aryl, substituted aryl, aromatic heterocycle, non-aromatic heterocycle, alcohol, ether, amine, cyano, sulfonyl, aldehyde, or aromatic group;
• L is alkylene, oxalkylene, or absent;
• wherein when L is absent the bonds attached to L do not exist;
• and
• each of E and G is independently N or C, wherein each of E and G is independently optionally substituted with R6.