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US 9,505,722 B2Granted
Azepane derivatives and methods of treating hepatitis B infections
AssigneeNovira Therapeutics, Inc.
InventorsGeorge D. Hartman, Scott Kuduk
Life of this patent
Estimating the term…
Abstract
Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of inhibiting, suppressing, or preventing HBV infection in the subject.
Claims20
A compound of Formula V:
- or a pharmaceutically acceptable salt thereof;
- wherein
- each R1 is, independently at each occurrence, halo, OH, —C1-C6 alkyl, or —O—C1-C6 alkyl, wherein the alkyl group is optionally substituted 1-3 times with halo or OH;
- each R2 is, independently at each occurrence, halo, OH, —C1-C6 alkyl, or —O—C1-C6 alkyl, wherein the alkyl group is optionally substituted 1-3 times with halo or OH;
- Cy is
- R11 is, independently at each occurrence, —OH, —C1-C6 alkyl, —OC(O)CH3, or —C3-C10 cycloalkyl;
- R13 and R14, together with the carbons to which they are attached, join to form a cyclopropyl ring;
- m is 1, 2, or 3;
- n is 1, 2, or 3;
- and
- x is 2 or 3.
8 more elements
Dependencies are inferred from the claim text.