Method of identifying a biologically-active composition from a biofilm
AssigneeQuorum Innovations, LLC
InventorsEva A. Berkes, Nicholas T. Monsul
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Abstract
The subject invention provides materials and methods that effectively support innate immunity and/or disperse pathogenic biofilms using readily available, nontoxic, natural substances, while supporting restoration of normal microbiotic homeostasis. In one embodiment, the subject invention provides anti-biofilm compositions comprising one or more probiotic organisms, anti-microbial honey, and other ingredients such as prebiotic compounds, other hive products, green tea derivatives, other plant derivatives, and vitamin D3.
Claims13
A method for identifying and selecting a biologically-active composition, wherein said method comprises:
- (1) growing a microbial biofilm on a substrate wherein said substrate upon which said biofilm is grown is contained within a reactor vessel and is contacted with a biological growth medium within said reactor vessel;
- (2) harvesting said biofilm by removing the biofilm from the substrate and separating the biofilm from the growth medium thereby obtaining a fraction comprising biofilm cellular mass;
- (3) testing said fraction of biofilm cellular mass for biological activity;
- (4) based on results of the testing in step (3), determining whether said fraction has biological activity;
- and (5) selecting, as the biologically-active composition, the fraction that is found to have biological activity;
- wherein said biological activity is anti-microbial activity or anti-inflammatory activity.
Dependencies are inferred from the claim text.