Cell membrane translocation of regulated snare inhibitors, compositions therefor, and methods for treatment of disease
OwnerIra Sandersinventor
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Abstract
Compositions and methods of modulating cellular function and treatment of disease in mammals comprising locally administering a regulated SNARE inhibitor and a translocating agent to the mammal. Regulated SNARE inhibitors include clostridial neurotoxins, tetanus neurotoxin and their free light chain portions and IgA protease. Translocating agents include acids, encapsulating vectors, and transduction domains.
Claims15
A method of treating headache pain in a mammal in need thereof comprising administering a therapeutically effective amount of a botulinum neurotoxin to treat headache pain into the mammal's pterygopalatine space, thereby blocking the mammal's sphenopalatine ganglion.
A method of treating headache pain in a mammal in need thereof comprising administering a therapeutically effective amount of botulinum neurotoxin serotype A to treat headache pain into the mammal's pterygopalatine space, thereby blocking the mammal's sphenopalatine ganglion.
Dependencies are inferred from the claim text.