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US 9,504,651 B2Granted
Lipid compositions for nucleic acid delivery
AssigneeProtiva Biotherapeutics, Inc.
InventorsIan MacLachlan, Lloyd Jeffs, Lorne R. Palmer, Cory Giesbrecht
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Abstract
The present invention provides apparatus and processes for producing liposomes. By providing a buffer solution in a first reservoir, and a lipid solution in a second reservoir, continuously diluting the lipid solution with the buffer solution in a mixing chamber produces a liposome. The lipid solution preferably comprises an organic solvent, such as a lower alkanol.
Claims14
A lipid vesicle formulation comprising:
- (a) a plurality of lipid vesicles, wherein each lipid vesicle comprises:
- a cationic lipid;
- an amphipathic lipid;
- and
- a polyethyleneglycol (PEG)-lipid;
- and
- (b) messenger RNA (mRNA), wherein at least 70% of the mRNA in the formulation is fully encapsulated in the lipid vesicles.
4 more elements
Dependencies are inferred from the claim text.