Ion generation using modified wetted porous materials
AssigneePurdue Research Foundation
InventorsRobert Graham Cooks, Zheng Ouyang, He Wang
Life of this patent
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Abstract
The invention generally relates to ion generation using modified wetted porous materials. In certain aspects, the invention generally relates to systems and methods for ion generation using a wetted porous substrate that substantially prevents diffusion of sample into the substrate. In other aspects, the invention generally relate to ion generation using a wetted porous material and a drying agent. In other aspects, the invention generally relates to ion generation using a modified wetted porous substrate in which at least a portion of the porous substrate includes a material that modifies an interaction between a sample and the substrate.
Claims20
A system for analyzing a sample material comprising:
- at least one porous substrate connected to a voltage source, wherein the porous substrate is coated with a material that substantially prevents diffusion of a sample into the substrate in a manner that the sample remains substantially on top of the substrate until a solvent is applied to the substrate;
- and
- a mass analyzer.
A method for analyzing a sample comprising:
- contacting a sample to a porous substrate, wherein the porous substrate is coated with a material that substantially prevents diffusion of a sample into the substrate in a manner that the sample remains substantially on top of the substrate until a solvent is applied to the substrate;
- applying a solvent that is capable of diffusing into the substrate to the sample, resulting in diffusion of components of the sample into the substrate;
- applying a voltage to the substrate to generate ions of the components that are expelled from the porous substrate;
- and
- analyzing the expelled ions.
A method for analyzing blood, the method comprising:
- contacting a blood sample to a porous substrate, wherein the porous substrate is coated with a material that substantially prevents diffusion of a sample into the substrate in a manner that the sample remains substantially on top of the substrate until a solvent is applied to the substrate;
- applying to the blood sample a solvent that is capable of diffusing into the substrate, resulting in diffusion of components of the blood sample into the substrate;
- applying a voltage to the substrate to generate ions of the components that are expelled from the porous substrate;
- and
- analyzing the expelled ions.
Dependencies are inferred from the claim text.