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US 9,499,544 B2Granted
Nitrogen containing heterocyclic compounds
AssigneeWockhardt Limited
InventorsSachin Bhagwat, Prasad Keshav Deshpande, Satish Bhawsar, Vijaykumar Jagdishwar Patil, Ravikumar Tadiparthi, Shivaji Sampatrao Pawar, Sunil Bhaginath Jadhav, Sanjay Kisan Dabhade, Vikas Vitthalrao Deshmukh, Bharat Dhond, Satish Birajdar, Mohammad Usman Shaikh, Deepak Dekhane, Piyush Ambalal Patel
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Abstract
Compounds of Formula (I), their preparation and use in preventing or treating bacterial infections are disclosed.
Claims18
A pharmaceutical composition comprising:
- (a) at least one antibacterial agent or a pharmaceutically acceptable derivative thereof;
- and (b) a compound of Formula (I)
- or a stereoisomer or a pharmaceutically acceptable salt thereof, wherein:
- Q is a heteroaryl selected from oxadiazole, thiadiazole and tetrazole;
- R1 is:
- (a) hydrogen,
- (b) (CO)n—R3, or
- (c) COOR4,
- n is 0 or 1;
- R2 is:
- (a) SO3M
- M is hydrogen or a cation;
- R3 is:
- (a) hydrogen,
- (b) C1-C6 alkyl optionally substituted with one or more substituents independently selected from halogen, OR5, CN, COOR5, CONR5R7, NR6R7, NR5COR8, NR5CONR6R7, heterocyclyl, heteroaryl, cycloalkyl and aryl,
- (c) NR6R7,
- (d) CONR6R7,
- (e) aryl optionally substituted with one or more substituents independently selected from C1-C6 alkyl, OR5, NR6R7, halogen, CN, CONR6R7, SO2-alkyl, SO2-aryl, OSO2-alkyl, OSO2-aryl, and NHCONR6R7,
- (f) heterocyclyl optionally substituted with one or more substituents independently selected from C1-C6 alkyl, OR5, NR6R7, halogen, CN, CONR6R7, SO2-alkyl, SO2-aryl, OSO2-alkyl, OSO2-aryl, and NHCONR6R7,
- (g) heteroaryl optionally substituted with one or more substituents independently selected from C1-C6 alkyl, OR5, NR6R7, halogen, CN, CONR6R7, SO2-alkyl, SO2-aryl, OSO2-alkyl, OSO2-aryl, and NHCONR6R7, or
- (h) OR8;
- R4 is:
- (a) hydrogen, or
- (b) C1-C6 alkyl optionally substituted with one or more substituents independently selected from halogen, OR5, CN, COOR5, CONR6R7, NR6R7, NR5COR8, heterocyclyl, heteroaryl, cycloalkyl and aryl;
- R5 and R8 are each independently:
- (a) hydrogen, or
- (b) C1-C6 alkyl optionally substituted with one or more substituents independently selected from halogen, CN, CONR6R7, NR6R7, heterocyclyl, heteroaryl, cycloalkyl and aryl;
- R6 and R7 are each independently:
- (a) hydrogen, or
- (b) C1-C6 alkyl optionally substituted with one or more substituents independently selected from halogen, OR5, CN, COOR5, CONR5R8, NR5R8, NR5COR8, heterocyclyl, heteroaryl, cycloalkyl and aryl.
27 more elements
Dependencies are inferred from the claim text.