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US 9,498,520 B2Granted
Use of proteases for gluten intolerance
AssigneesAmano Enzyme Inc., Amano Enzyme U.S.A. Co., Ltd.
InventorsJames F. Jolly, Horoki Ido, Hirotaka Matsubara, Tetsuya Takahashi, Kyoichi Nishio
Life of this patent
Estimating the term…
Abstract
The present technology relates to an enzyme composition. The enzyme composition may be used to treat gluten intolerant subjects, including suffering from non-Celiac gluten intolerance and/or non-Celiac gluten sensitivity. The enzyme composition may also be used to reduce gluten exposure in certain individuals. For example, the enzyme composition may also be used as a prophylactic to reduce exposure to gluten oligopeptides.
Claims7
A method of treating gluten intolerance or reducing gluten exposure in a human subject comprising:
- orally administering the subject with a therapeutically effective amount of an enzyme cocktail comprising a gluten degrading enzyme preparation isolated from Aspergillus oryzae with specificity for peptide substrate leucyl-glycyl-glycine (GDEP-LGG), papain, a semi-alkali protease and an enzyme preparation from Penicillium citrinum,
- wherein the enzyme cocktail degrades a gluten oligopeptide of SEQ ID NO:1 into peptide fragments of four amino acids or less at acidic conditions, and
- wherein the GDEP-LGG and papain are in a percent relative activity ratio of 80:20 to 20:80.
Dependencies are inferred from the claim text.