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US 9,493,810 B2Granted
5-ALA for detection of brain tumors
AssigneePioma, Inc.
InventorAlan M. Ezrin
Life of this patent
Estimating the term…
Abstract
The present disclosure relates to methods for detecting brain tumors and assessing the recurrence of such tumors by administering a pharmaceutical composition comprising 5-aminolevulinic acid (5-ALA) and detecting the conversion of 5-ALA to protoporphyrin IX (PPIX) associated with brain-derived microparticles.
Claims20
A method for detecting a WHO grade III or grade IV brain tumor, wherein the method comprises
- administering a pharmaceutical composition comprising 5-aminolevulinic acid (5-ALA) to a subject;
- isolating microvesicles from a biological sample from the subject;
- and
- detecting the level of conversion of 5-ALA to protoporphyrin IX (PPIX) associated with microvesicles shed from the WHO grade III or grade IV brain tumor in the biological sample from the subject, thereby detecting the WHO grade III or grade IV brain tumor.
1 more element
A method for assessing the recurrence of WHO grade III and grade IV brain tumors, wherein the method comprises
- administering a pharmaceutical composition comprising 5-aminolevulinic acid (5-ALA) to a subject;
- isolating microvesicles from a biological sample from the subject;
- and
- assessing the recurrence of WHO grade III and grade IV brain tumors by detecting 5-ALA associated with microvesicles shed from the WHO grade III or grade IV brain tumor in the biological sample from the subject.
1 more element
Dependencies are inferred from the claim text.