Biologically active complex and its preparation
AssigneeHamlet Pharma AB
InventorsCatharina Svanborg, Kenneth Hun Mok, Maria Trulsson, Ann-Kristin Mossberg, Petter Storm, Ching Shing Ho
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Abstract
A biologically active complex comprising either a polypeptide having the sequence of a variant of a naturally occurring protein, wherein said polypeptide is at least partially unfolded as compared to the said naturally occurring protein; or a peptide of up to 50 amino acids, for instance a fragment of the naturally occurring protein or a variant thereof; and a pharmaceutically acceptable salt of a fatty acid or lipid. The complexes of the invention demonstrate a novel mode of action, which gives rise to opportunities for the development of further active agents and screening methods.
Claims19
A biologically active complex comprising a peptide comprising the sequence LDDDITDDIMXAKKILDIKGIDYWLAHKALXTEKLEQWLXEKL (SEQ ID NO:
- 4), wherein X is an amino acid residue other than cysteine and the peptide is up to 50 amino acids in length;
- and a pharmaceutically acceptable salt of a fatty acid or lipid.
A method for preparing a biologically active complex comprising a peptide comprising SEQ ID NO:
- 4, wherein the peptide is up to 50 amino acids in length, and a pharmaceutically acceptable salt of a fatty acid or lipid, wherein the method comprises mixing together the peptide and the salt of the fatty acid or lipid.
A method for treating cancer, the method comprises administering to a patient in need thereof a biologically active complex comprising a peptide comprising SEQ ID NO:
- 4, wherein the peptide is up to 50 amino acids in length, and a pharmaceutically acceptable salt of a fatty acid or lipid, or a pharmaceutical composition comprising the biologically active complex;
- wherein the cancer is selected from the group consisting of lung carcinoma, kidney cancer, T cell lymphoma and ovarian cancer.
A kit comprising a peptide comprising SEQ ID NO:
- 4, wherein the peptide is a peptide of up to 50 amino acids in length, and a pharmaceutically acceptable salt of a fatty acid or lipid.
A peptide comprising SEQ ID NO:
- 4, wherein the peptide is up to 50 amino acids in length.
Dependencies are inferred from the claim text.