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US 9,487,521 B2Granted
Processes and intermediates for making a JAK inhibitor
AssigneesIncyte Holdings Corporation, Incyte Corporation
InventorsJiacheng Zhou, Yongzhong Wu, Pingli Liu, Ganfeng Cao
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Abstract
This invention relates to processes and intermediates for making {1-{1-[3-fluoro-2-(trifluoromethyl)isonicotinoyl]piperidin-4-yl}-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-yl}acetonitrile, useful in the treatment of diseases related to the activity of Janus kinases (JAK) including inflammatory disorders, autoimmune disorders, cancer, and other diseases.
Claims16
A process, comprising reacting a compound of Formula III:
- or a salt thereof, with a compound of Formula IV:
- in the presence of a reducing agent to form a compound of Formula II:
- or a salt thereof, provided said reducing agent is not sodium cyanoborodeuteride;
- wherein P1 is a protecting group.
1 more element
Dependencies are inferred from the claim text.