Bordetella outer-membrane protein antigens and methods of making and using the same
AssigneeWake Forest University Health Sciences
InventorsRajendar K. Deora, Meenu Mishra, Neelima Sukumar
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Abstract
An isolated protein or peptide selected from the group consisting of Bordetella colonization factor A (BcfA) protein and antigenic fragments thereof is described, along with an isolated nucleic acid encoding the same, antibodies that bind to the same, methods of producing an immune response in a mammalian subject in need thereof by administering the proteins, peptides or antibodies, and pharmaceutical compositions comprising the same.
Claims15
A method of producing an immune response in a mammalian subject in need thereof, comprising administering to said subject an isolated protein or peptide comprising (i) the Bordetella colonization factor A (BcfA) protein of SEQ ID NO:
- 2 or (ii) and antigenic fragments thereof comprising 20 or more contiguous amino acids thereof, in an amount effective to produce an immune response.
A method of producing an immune response in a mammalian subject in need thereof, comprising administering to said subject an isolated Bordetella colonization factor A (BcfA) peptide comprising an antigenic fragment of 20 or more contiguous amino acids of SEQ ID NO:
- 2 in an amount effective to produce an immune response.
Dependencies are inferred from the claim text.