Methods of using adipose tissue-derived cells in the treatment of the lymphatic system and malignant disease
AssigneeCytori Therapeutics, Inc.
InventorsZeni Alfonso, John K. Fraser
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Abstract
Aspects of the invention provides methods for preparing and using adipose-tissue-derived stem and progenitor cells, adipose-tissue-derived lymphatic endothelial cells, and cells capable of differentiating into lymphatic endothelial cells to treat disorders of the lymphatic system and to modulate expansion, repair, and/or regeneration of the lymphatic system. The invention further provides using adipose-tissue-derived lymphatic endothelial cells and cells capable of differentiating into lymphatic endothelial cells for delivery of therapeutic agents to tumor cells as a means for treating malignant disease, and assays to screen for drugs that modulate lymphatic system expansion, repair or regeneration.
Claims20
A method of treating edema in a subject in need thereof, comprising:
- identifying a subject having edema;
- and
- administering to said subject an isolated population of adipose-derived cells comprising lymphatic endothelial cells (LECs) and pre-LECs, wherein greater than 5% of said population of adipose-derived cells express FLT-4.
Dependencies are inferred from the claim text.