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US 9,486,437 B2Granted
Methods of using low-dose doxepin for the improvement of sleep
AssigneesPernix Sleep, Inc., ProCom One, Inc.
InventorsRoberta L. Rogowski, Susan E. Dubé, Philip Jochelson, Neil B. Kavey
Life of this patent
Estimating the term…
Abstract
Methods of preventing early awakenings, and improving sleep efficiency in hours 7 and 8 of a period of sleep, by administration of low doses of doxepin (e.g., 1-6 mg).
Claims18
A method for treating sleep maintenance insomnia characterized by fragmented sleep during the 8th hour of sleep, the method comprising:
- administering a dosage of doxepin or a pharmaceutically acceptable salt thereof to a patient having a sleep disorder in which, for a given 8 hour period of desired sleep, the patient experiences fragmented sleep during the final 60 minutes of said period, wherein the dosage of doxepin is between about 0.5 and about 6 mg and is administered prior to the start of the sleep period.
A method for treating sleep maintenance insomnia characterized by early awakenings during the 8th hour of sleep, the method comprising:
- administering a dosage of doxepin or a pharmaceutically acceptable salt thereof to a patient having a sleep disorder in which, for a given 8 hour period of desired sleep, the patient experiences early awakenings during the final 60 minutes of said period, wherein the dosage of doxepin is between about 0.5 and about 6 mg and is administered prior to the start of the sleep period.
Dependencies are inferred from the claim text.