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US 9,481,698 B2Granted
Process for preparing ceftaroline fosamil
AssigneeSandoz Ltd.
InventorsHubert Sturm, Josef Wieser
Life of this patent
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Abstract
The present invention relates to a novel process for preparing ceftaroline fosamil as well as to intermediates of this process.
Claims11
A compound having the formula (1)
- wherein
- Phos is a phosphate group;
- and
- X is a cation selected from the group consisting of a magnesium cation and an imidazolium cation which can be optionally substituted by one or more C1-6 alkyl groups;
- as well as a pharmaceutically acceptable solvate thereof selected from an acetic acid solvate or an acetonitrile solvate.
2 more elements
A process comprising the steps of:
- (i) reacting a compound having the formula (2) or a salt thereof
- with a compound having the formula (3)
- wherein Hal is a halogen;
- and
- (ii) adding a reagent selected from the group consisting of a magnesium salt and an imidazole which can be optionally substituted by one or more C1-6 alkyl groups;
- to provide a compound having the formula (1)
- wherein
- Phos is a phosphate group;
- and
- X is a cation selected from the group consisting of a magnesium cation and an imidazolium cation which can be optionally substituted by one or more C1-6 alkyl groups.
7 more elements
A process comprising the steps of:
- (a) reacting a compound having the formula (2) or a salt thereof
- with a silane to provide a compound having the formula (5)
- wherein R is independently selected from a C1-6 alkyl group;
- (b) reacting the compound having the formula (5) with a compound having the formula (3)
- wherein Hal is a halogen;
- (c) removing the silyl group —SiR3 from the resultant compound;
- and
- (d) adding a reagent selected from the group consisting of a magnesium salt and an imidazole which can be optionally substituted by one or more C1-6 alkyl groups;
- to provide a compound having the formula (1)
- wherein
- Phos is a phosphate group;
- and
- X is a cation selected from the group consisting of a magnesium cation and an imidazolium cation which can be optionally substituted by one or more C1-6 alkyl groups.
10 more elements
Dependencies are inferred from the claim text.