Back to results
US 9,481,636 B2Granted
N-benzylaniline derivative and uses thereof
AssigneeNanjing Medical University
InventorsDongya Zhu, Fei Li, Chunxia Luo
Life of this patent
Estimating the term…
Abstract
A N-benzylaniline derivative and uses thereof. The derivative is a compound represented by formula I or a pharmaceutically acceptable salt thereof. The compound protects against cerebral ischemia/reperfusion injury and has analgesic action for chronic pathologic pain, and may be used to treat cerebral apoplexy, neuropathic pain, and inflammatory pain. Moreover, because of the unique mechanism of action of the compound, the compound can be used to treat epilepsy, affective disorder, and neurodegenerative diseases.
Claims11
An N-benzylaniline derivative having the structure of general formula (I),
- wherein,
- R1 is hydroxyl, C1-C6 alkoxy or —OCOR11;
- R2, R3, R5, R6, R9 or R10 is each independently hydrogen, halogen or trifluoromethyl;
- R4 is halogen or trifluoromethyl;
- R7 is —COR12, hydroxyl, C1-C6 alkoxy, —OCH2COR12, —OCOR11 or —OCH2COB;
- R8 is —COR12, hydroxyl, —OCH2COR12, —OCOR11 or —OCH2COB;
- X is hydrogen or C1-C6 alkyl;
- Y is hydrogen, C1-C6 alkyl, —CH2COR13 or —COR13;
- R11 is C1-C6 alkyl or B;
- R12 is C1-C6 alkyl, hydroxyl, C1-C6 alkoxy or B;
- R13 is C1-C6 alkyl, C1-C6 alkoxy or B;
- B is
- wherein at least one of R7, R8 and Y contains B group,
- or a pharmaceutically acceptable salt thereof.
11 more elements
Dependencies are inferred from the claim text.