Bovine virus vaccines that are liquid stable
AssigneeIntervet Inc.
InventorsBrad Eddy, Zhisong Qiao, Kevin O'Connell
Life of this patent
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Abstract
The present invention discloses liquid stable bovine vaccines that comprise a live attenuated virus, and a sugar alcohol. The present invention also discloses the manufacture of such vaccines and methods of protecting an animal by administration of such vaccines.
Claims20
A liquid stable vaccine that comprises a live attenuated bovine virus, a 5-40% (w/v) sugar alcohol, and 0.15 to 0.75 M of an amino acid selected from the group consisting of arginine, glutamic acid, and glycine;
- wherein the liquid stable vaccine has a pH of 6.0 to 8.0;
- and
- wherein the live attenuated bovine virus is selected from the group consisting of a bovine viral diarrhea virus (BVDV), an infectious bovine rinotracheitis virus (IBR), a parainfluenza type 3 virus (PI3), a bovine respiratory syncytial virus (BRSV), and any combination thereof.
A method of making a liquid stable bovine vaccine that comprises combining a therapeutically effective amount of a live attenuated bovine virus with a 5-40% (w/v) sugar alcohol, 0.15 to 0.75 M arginine;
- wherein the live attenuated bovine virus is selected from the group consisting of a bovine viral diarrhea virus (BVDV), an infectious bovine rinotracheitis virus (IBR), a parainfluenza type 3 virus (PI3), a bovine respiratory syncytial virus (BRSV), and any combination thereof;
- and
- wherein the liquid stable vaccine has a pH of 6.0 to 8.0.
Dependencies are inferred from the claim text.