Sulfated-oxysterol and oxysterol sulfation by hydroxysterol sulfotransferase promote lipid homeostasis and liver proliferation
AssigneeVirginia Commonwealth University
InventorShunlin Ren
Life of this patent
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Abstract
Methods and compositions for the prevention and treatment of liver damage or disease in a subject in need thereof are provided. The methods involve providing the sulfated oxysterol 25-hydroxycholesterol-3-sulfate (25HC3S) to the subject e.g. by 1) administering 25HC3S to the subject; or 2) overexpressing, in the subject, the hydroxysterol sulfotransferase enzyme SULT2B1b, which catalyzes the sulfation of 25-hydroxycholesterol (25HC) to form 25HC3S.
Claims22
A method for promoting hepatocyte proliferation in a liver surgery subject, comprising:
- identifying the liver surgery subject, wherein the liver surgery subject is in need of hepatocyte proliferation, and
- elevating a level of 25-hydroxycholesterol-3-sulfate (25HC3S) in the liver surgery subject, during or after liver surgery, by
- administering to the liver surgery subject a composition comprising
- 25HC3S and
- a physiologically compatible carrier,
- wherein the elevating promotes hepatocyte proliferation in the liver surgery subject.
A method for promoting liver tissue regeneration in a liver surgery subject, comprising:
- identifying the liver surgery subject, wherein the liver surgery subject is in need of liver tissue regeneration, and
- elevating a level of 25-hydroxycholesterol-3-sulfate (25HC3S) in the liver surgery subject, during or after liver surgery, by
- administering to the liver surgery subject a composition comprising
- 25HC3S and
- a physiologically compatible carrier,
- wherein the elevating promotes liver tissue regeneration in the liver surgery subject.
Dependencies are inferred from the claim text.