Adenoviral vectors for transduction of vascular tissue
AssigneeJanssen Vaccines & Prevention B.V.
InventorsAndrew Baker, Stuart Nicklin, Alan Parker
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Abstract
The invention relates to the field of gene transfer, and in particular to the use of adenoviral vectors of serotype Ad49 for gene delivery to vascular tissue.
Claims15
A method of gene delivery or gene transfer to a vascular cell or tissue comprising contacting said vascular cell or tissue with an adenoviral gene delivery vehicle, wherein the adenoviral gene delivery vehicle comprises an Ad49 hexon protein, an Ad49 penton protein, an Ad49 fiber protein, and a nucleic acid payload comprising a heterologous gene, thereby providing a genetically modified cell or tissue.
A method of gene delivery or gene transfer to a human smooth muscle cell (hSMC) comprising contacting the hSMC with an adenoviral gene delivery vehicle, wherein the adenoviral gene delivery vehicle comprises an Ad49 hexon protein, an Ad49 penton protein, an Ad49 fiber protein, and a nucleic acid payload comprising a heterologous gene, thereby providing a genetically modified hSMC.
Dependencies are inferred from the claim text.