Compositions for inhibiting MASP-2 dependent complement activation
AssigneeOmeros Corporation
InventorsThomas Dudler, Wayne R. Gombotz, James Brian Parent, Clark E. Tedford, Anita Kavlie, Urs Beat Hagemann, Herald Reiersen, Sergej Kiprijanov
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Abstract
The present invention relates to anti-MASP-2 inhibitory antibodies and compositions comprising such antibodies for use in inhibiting the adverse effects of MASP-2 dependent complement activation.
Claims31
An isolated human monoclonal antibody, or antigen binding fragment thereof, that binds to human MASP-2, comprising:
- (i) a heavy chain variable region comprising three complementarity determining regions (CDRs), comprising a CDR-H1 comprising the amino acid sequence STSAA (SEQ ID NO:29), a CDR-H2 comprising the amino acid sequence LGRTYYRSKWYNDYAV (SEQ ID NO:33), and a CDR-H3 comprising the amino acid sequence AVYYCARD (SEQ ID NO:38);
- and
- (ii) a light chain variable region comprising three CDRs, comprising a CDR-L1 comprising the amino acid sequence GXNXGXKXVHW (SEQ ID NO:92), wherein X at position 2 is N or D and wherein X at position 4 is I or L and wherein X at position 6 is S or K and wherein X at position 8 is N or R, a CDR-L2 comprising the amino acid sequence DSDRPSG (SEQ ID NO:49), and CDR-L3 comprising the amino acid sequence VWDXXTDHV (SEQ ID NO:94), wherein X at position 4 is T or I and wherein X at position 5 is T or A, and wherein the isolated antibody or antigen-binding fragment thereof binds to human MASP-2 and inhibits MASP-2 dependent complement activation.
An isolated monoclonal antibody, or antigen-binding fragment thereof, that binds to human MASP-2, comprising a heavy chain variable region comprising the amino acid sequence set forth in SEQ ID NO:21 and a light chain variable region comprising the amino acid sequence set forth in SEQ ID NO:25.
An isolated monoclonal antibody, or antigen-binding fragment thereof, that binds to human MASP-2, comprising a heavy chain variable region comprising the amino acid sequence set forth in SEQ ID NO:21 and a light chain variable region comprising the amino acid sequence set forth in SEQ ID NO:27.
Dependencies are inferred from the claim text.