Compositions and methods for the treatment of urea cycle disorders and gout
OwnerMohan Murali Alapatiinventor
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Abstract
The disclosures herein provide compounds of Formula I, Formula II, Formula III, Formula IV, Formula V, Formula VI and Formula VII or its pharmaceutical acceptable compositions and salts, as well as polymorphs, enantiomers, stereoisomers, solvates, and hydrates thereof. The pharmaceutical compositions may be formulated for oral administration, delayed release or sustained release, transmucosal, syrup, topical, parenteral administration, injection, subdermal, oral solution, rectal administration, nanoparticle, buccal administration or transdermal administration. Such compositions may be used to treatment of urea cycle disorders and gout or its associated complications.
Claims15
A compound of Formula I:
- or salts, pharmaceutically acceptable salts, hydrates, solvates, crystals, esters, enantiomers, or stereoisomers thereof, or mixtures thereof, wherein:
- R1 independently represents CD3, CD2, CD3CO, NULL,
- and
- R2 independently represents NULL,
- n is independently 1, 2, 3, 4 or 5;
- a is independently 2, 3 or 7;
- each b is independently 3, 5 or 6;
- e is independently 1, 2 or 6;
- c and d are each independently H, D, —OH, −OD, C1-C6-alkyl, —NH2 or —COCH3.
A compound of Formula II:
- or pharmaceutically acceptable salts, hydrates, solvates, enantiomers, stereoisomers, crystals, or mixtures thereof;
- and
- comprising at least one X− or Y+, or a mixture thereof, wherein:
- X− independently represents at least one of
- and
- Y+ independently represents at least one of
- sodium, potassium, megluminium, piperazinium, choline or ethanolaminium.
A compound of Formula III:
- or pharmaceutically acceptable salts, hydrates, solvates, enantiomers, and stereoisomers, crystals, or mixtures thereof, and comprising at least one X− or y+, or a mixture thereof, wherein:
- X− independently represents at least one of
- and
- Y+ independently represents at least one of
- sodium, potassium, megluminium, piperazinium, choline or ethanolaminium.
Dependencies are inferred from the claim text.