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US 9,469,669 B2Granted
Isoxazolidine derivatives
AssigneeChiesi Farmaceutici S.p.A.
InventorEleonora Ghidini
Life of this patent
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Abstract
Glucocorticosteroids that are derivatives of isoxazolidine are useful as anti-inflammatory and antiallergic compounds of the glucocorticosteroid series.
Claims5
A method for the treatment of asthma or Chronic Obstructive Pulmonary Disease (COPD), comprising administering to a subject in need thereof an effective amount of a compound of formula (I):
- wherein
- R1 is linear or branched (C1-C16)alkyl, linear or branched (C2-C18)alkenyl, —OR6, aryl, aryl(C1-C16)alkyl, —SR6, —N(R4)(R5), (C3-C8)cycloalkyl, (C3-C8)heterocycloalkyl, or heteroaryl, wherein optionally one or more hydrogen atoms are replaced by (C1-C6)alkyl, and wherein R4 and R5 are independently H or linear or branched (C1-C6)alkyl, and R6 is linear or branched (C1-C16)alkyl;
- R2 is aryl optionally substituted by one or more halogen atoms,
- or a pharmaceutically acceptable salt thereof.
1 more element
Dependencies are inferred from the claim text.