Back to results
US 9,464,276 B2Granted
Highly efficient influenza matrix (M1) proteins
AssigneeNovavax, Inc.
InventorsGale Smith, Yingyun Wu, Michael Massare, Peter Pushko, Margaret Nathan, Thomas Kort, Robin Robinson
Life of this patent
Estimating the term…
Abstract
This invention discloses a method of increasing production of virus-like particles comprising expressing an avian influenza matrix protein. The invention also comprises methods of making and using said VLPs.
Claims16
A method of increasing production of a VLP comprising expressing a mutated influenza M1 protein, an influenza HA protein, and an influenza NA protein in a host cell,
- wherein the mutated influenza M1 protein comprises an Arginine to Lysine mutation at the position corresponding to position 101 of SEQ ID NO:
- 49, wherein increased VLP release from the host cell is obtained with the M1 protein having the Lysine compared to VLP release obtained with an M1 protein having Arginine at the position corresponding to position 101 of SEQ ID NO:
- 49.
Dependencies are inferred from the claim text.