Recombinant viral vectors and methods for inducing a heterosubtypic immune response to influenza A viruses
AssigneeBaxalta Incorporated
InventorsFalko-Günter Falkner, Birgit Schafer, P. Noel Barrett, Thomas R. Kreil, Hartmut Ehrlich, Annett Hessel
Life of this patent
Estimating the term…
Abstract
The present invention relates to recombinant viral vectors and methods of using the recombinant viral vectors to induce an immune response to influenza A viruses. The invention provides recombinant viral vectors based, for example, on the non-replicating modified vaccinia virus Ankara. When administered according to methods of the invention, the recombinant viral vectors are designed to be cross-protective and induce heterosubtypic immunity to influenza A viruses.
Claims3
A recombinant modified vaccinia virus Ankara (rMVA) comprising a first gene cassette encoding an influenza A headless hemagglutinin (hlHA) polypeptide of SEQ ID NO:
- 15 and a second gene cassette encoding influenza A nucleoprotein (NP).
Dependencies are inferred from the claim text.