Method for treatment of diabetes by a small molecule inhibitor for GRK5

The method according to claim A, wherein the at least one inhibitor is selected from the group consisting of:

• 4-(6-benzylimidazo[1,2-b]pyridazin-3-yl)benzamide, 6-(1-methylpyrazol-4-yl)-3-(2-thienyl)imidazo[1,2-b]pyridazine, N-(2-dimethylaminoethyl)-3-[6-(4-hydroxy-3-methoxy-phenyl)imidazo[1,2-b]pyridazin-3-yl]benzamide, (2S)-2-[[3-(4-aminophenyl)imidazo[1,2-b]pyridazin-6-yl]amino]-3-methyl-butan-1-ol, 3-(2,4-dimethoxyphenyl)-N-(2-thienylmethyl)imidazo[1,2-b]pyridazin-6-amine, 4-[6-(2-methoxyethylamino)imidazo[1,2-b]pyridazin-3-yl]-N-(4-methoxyphenyl)benzamide, 2-[[3-[(E)-hex-1-enyl]imidazo[1,2-b]pyridazin-6-yl]amino]butan-1-ol, 2-[[3-(2-chlorophenyl)imidazo[1,2-b]pyridazin-6-yl]amino]butan-1-ol, 3-(3-pyridyl)-6-(3,4,5-trimethoxyphenyl)imidazo[1,2-b]pyridazine, 6-(3,4-dimethoxyphenyl)-3-(4-pyridyl)imidazo[1,2-b]pyridazine, N-[3-[3-(3-acetamidophenyl)imidazo[1,2-b]pyridazin-6-yl]phenyl]acetamide, 2-methoxy-4-[6-(3,4,5-trimethoxyphenyl)imidazo[1,2-b]pyridazin-3-yl]phenol, N-(2-dimethylaminoethyl)-3-[6-[3-(methanesulfonamido)phenyl]imidazo[1,2-b]pyridazin-3-yl]benzamide, N-[(3-chlorophenyl)methyl]-3-[4-(trifluoromethoxy)phenyl]imidazo[1,2-b]pyridazin-6-amine, 4-[6-[(3-chlorophenyl)methylamino]imidazo[1,2-b]pyridazin-3-yl]-2-methoxy-phenol, methyl 4-[6-[(3-chlorophenyl)methylamino]imidazo[1,2-b]pyridazin-3-yl]benzoate, N-[(4-fluorophenyl)methyl]-3-(3-thienyl)imidazo[1,2-b]pyridazin-6-amine, N-[3-[6-[(4-fluorophenyl)methylamino]imidazo[1,2-b]pyridazin-3-yl]phenyl]acetamide, 4-[6-(propylamino)imidazo[1,2-b]pyridazin-3-yl]benzoic acid, (E)-3-[3-[6-(propylamino)imidazo[1,2-b]pyridazin-3-yl]phenyl]prop-2-enoic acid, 3-(3-aminophenyl)-N-[(3,4-dichlorophenyl)methyl]imidazo[1,2-b]pyridazin-6-amine, 3-(4-fluorophenyl)-N-(2-methoxyethyl)imidazo[1,2-b]pyridazin-6-amine, 3-(4-morpholinophenyl)-N-[2-(3-pyridyl)ethyl]imidazo[1,2-b]pyridazin-6-amine, 3-(2-naphthyl)-N-[2-(3-pyridyl)ethyl]imidazo[1,2-b]pyridazin-6-amine, N-(1,3-benzodioxol-5-ylmethyl)-3-(4-morpholinophenyl)imidazo[1,2-b]pyridazin-6-amine, N-(1,3-benzodioxol-5-ylmethyl)-3-(8-quinolyl)imidazo[1,2-b]pyridazin-6-amine, N-(1,3-benzodioxol-5-ylmethyl)-3-(4-chlorophenyl)imidazo[1,2-b]pyridazin-6-amine, 3-(2-fluorophenyl)-N-(2-methoxyethyl)imidazo[1,2-b]pyridazin-6-amine, (E)-3-[3-[6-(1,3-benzodioxol-5-ylmethylamino)imidazo[1,2-b]pyridazin-3-yl]phenyl]prop-2-enoic acid, 3-(2-phenoxyphenyl)-N-(4-pyridylmethyl) imidazo[1,2-b]pyridazin-6-amine, 4-[(3-bromoimidazo[1,2-b]pyridazin-6-yl)amino]cyclohexanol, 3-(3-aminophenyl)-N-tetrahydropyran-4-yl-imidazo[1,2-b]pyridazin-6-amine, 3-(4-phenoxyphenyl)-N-tetrahydropyran-4-yl-imidazo[1,2-b]pyridazin-6-amine, 3-(benzofuran-2-yl)-N-[(4-methoxyphenyl)methyl]imidazo[1,2-b]pyridazin-6-amine, 4-[6-[(4-methoxyphenyl)methylamino]imidazo[1,2-b]pyridazin-3-yl]phenol, 3-(1H-indol-5-yl)-N-[(4-methoxyphenyl)methyl]imidazo[1,2-b]pyridazin-6-amine, 3-(1-naphthyl)-N-[2-(2-pyridyl)ethyl]imidazo[1,2-b]pyridazin-6-amine, 3-(2,4-dimethoxyphenyl)-N-[(4-methoxyphenyl)methyl]imidazo[1,2-b]pyridazin-6-amine, 3-[[3-(2-furyl)imidazo[1,2-b]pyridazin-6-yl]amino]propan-1-ol, 3-[[3-(4-methoxyphenyl)imidazo[1,2-b]pyridazin-6-yl]amino]propan-1-ol, 3-[[3-(2,4-dimethoxyphenyl)imidazo[1,2-b]pyridazin-6-yl]amino]propan-1-ol, N-(3-morpholinopropyl)-3-(3,4,5-trimethoxyphenyl)imidazo[1,2-b]pyridazin-6-amine, 3-bromo-N-(3-morpholinopropyl)imidazo[1,2-b]pyridazin-6-amine (2S)-3-methyl-2-[[3-(2-naphthyl)imidazo[1,2-b]pyridazin-6-yl]amino]butan-1-ol, (2S)-2-[[3-(2,4-dimethoxyphenyl)imidazo[1,2-b]pyridazin-6-yl]amino]-3-methyl-butan-1-ol, 3-(3,4-dimethoxyphenyl)-N-(2-pyridylmethyl)imidazo[1,2-b]pyridazin-6-amine, 3-(5-isopropyl-2-methoxy-phenyl)-N-(2-pyridylmethyl)imidazo[1,2-b]pyridazin-6-amine, 3-(4-dimethylaminophenyl)-N-[(3,4,5-trimethoxyphenyl)methyl]imidazo[1,2-b]pyridazin-6-amine, N′,N′-dimethyl-N-[3-(p-tolyl)imidazo[1,2-b]pyridazin-6-yl]ethane-1,2-diamine, N-(cyclopropylmethyl)-3-(6-methoxy-3-pyridyl)imidazo[1,2-b]pyridazin-6-amine, 4-[6-[(2,4-dimethylphenyl)methylamino]imidazo[1,2-b]pyridazin-3-yl]phenol, 3-[4-[6-[(2,4-dimethylphenyl)methylamino]imidazo[1,2-b]pyridazin-3-yl]phenyl]propanoic acid, N-(2-dimethylaminoethyl)-4-[6-[(2,4-dimethylphenyl)methylamino]imidazo[1,2-b]pyridazin-3-yl]benzamide, N-[(2,4-dimethylphenyl)methyl]-3-(3-methoxyphenyl)imidazo[1,2-b]pyridazin-6-amine, 4-[[[3-(1,3-benzodioxol-5-yl)imidazo[1,2-b]pyridazin-6-yl]amino]methyl]benzenesulfonamide, 4-[[[3-(1-benzylpyrazol-4-yl)imidazo[1,2-b]pyridazin-6-yl]amino]methyl]benzenesulfonamide, 4-[6-[[4-(4-methylpiperazin-1-yl)phenyl]methylamino]imidazo[1,2-b]pyridazin-3-yl]benzonitrile, (Z)-5-[6-(methylamino)imidazo[1,2-b]pyridazin-3-yl]pent-4-en-1-ol, 2-[6-(methylamino)imidazo[1,2-b]pyridazin-3-yl]phenol, N,N-dimethyl-3-[6-(methylamino)imidazo[1,2-b]pyridazin-3-yl]benzamide, 1-[2-[6-(methylamino)imidazo[1,2-b]pyridazin-3-yl]phenyl]ethanone, 3-[4-(dimethylaminomethyl)phenyl]-N-methyl-imidazo[1,2-b]pyridazin-6-amine, 3-(3,3-dimethylbut-1-ynyl)-N-methyl-imidazo[1,2-b]pyridazin-6-amine, N-[2-[6-(methylamino)imidazo[1,2-b]pyridazin-3-yl]phenyl]acetamide, 3-methyl-4-[6-(methylamino)imidazo[1,2-b]pyridazin-3-yl]phenol, 3-[(5-imidazo[1,2-b]pyridazin-3-yl-2-pyridyl)oxy]-N,N-dimethyl-propan-1-amine, 1-(2-imidazo[1,2-b]pyridazin-3-ylphenyl)-N,N-dimethyl-methanamine, 3-[6-(4-methylpiperazin-1-yl)-3-pyridyl]imidazo[1,2-b]pyridazine, 3-(benzothiophen-2-yl)-N-[(3,4,5-trimethoxyphenyl)methyl]imidazo[1,2-b]pyridazin-6-amine, 3-dibenzofuran-4-ylimidazo[1,2-b]pyridazine, 3-(4-methylsulfanylphenyl)imidazo[1,2-b]pyridazine, 3-(4-chlorophenyl)imidazo[1,2-b]pyridazine, 3-[(E)-styryl]imidazo[1,2-b]pyridazine, 2-imidazo[1,2-b]pyridazin-3-ylbenzoic acid, 3-(3-ethoxyphenyl)imidazo[1,2-b]pyridazine, 4-imidazo[1,2-b]pyridazin-3-yl-2,6-dimethyl-phenol, N-(2-hydroxyethyl)-4-imidazo[1,2-b]pyridazin-3-yl-benzamide, (4-imidazo[1,2-b]pyridazin-3-ylphenyl)-(4-methylpiperazin-1-yl)methanone, 3-(2, 3-dihydrobenzofuran-5-yl)imidazo[1,2-b]pyridazine, 3-(3-fluoro-4-methyl-phenyl)imidazo[1,2-b]pyridazine, 3-imidazo[1,2-b]pyridazin-3-ylbenzonitrile, 3-(3,4-difluorophenyl)imidazo[1,2-b]pyridazine, 3-(m-tolyl)imidazo[1,2-b]pyridazine, 3-(4-ethoxyphenyl)imidazo[1,2-b]pyridazine, 3-(2-methylsulfanylphenyl)imidazo[1,2-b]pyridazine, 1-(4-imidazo[1,2-b]pyridazin-3-ylphenyl)ethanone, 5-imidazo[1,2-b]pyridazin-3-ylquinoline, N-cyclopropyl-4-imidazo[1,2-b]pyridazin-3-yl-benzamide, 4-imidazo[1,2-b]pyridazin-3-ylisoquinoline, (2-imidazo[1,2-b]pyridazin-3-ylphenyl)methanol, 3-(2-fluoro-3-methoxy-phenyl)imidazo[1,2-b]pyridazine, (3-imidazo[1,2-b]pyridazin-3-ylphenyl)-morpholino-methanone, 2-(4-imidazo[1,2-b]pyridazin-3-ylphenyl)acetonitrile, N-(2-furylmethyl)-3-imidazo[1,2-b]pyridazin-3-yl-benzamide, N-(4-imidazo[1,2-b]pyridazin-3-ylphenyl)methanesulfonamide, 4-[(4-imidazo[1,2-b]pyridazin-3-ylphenyl)methyl]morpholine, 3-(1-isobutylpyrazol-4-yl)imidazo[1,2-b]pyridazine, N-cyclopropyl-3-imidazo[1,2-b]pyridazin-3-yl-benzamide, 4-(3-phenylimidazo[1,2-b]pyridazin-6-yl)benzamide, 3-(1,3-benzodioxol-5-yl)-6-phenyl-imidazo[1,2-b]pyridazine, 3-(1,3-benzodioxol-5-yl)-6-[3-(trifluoromethyl)phenyl]imidazo[1,2-b]pyridazine, 3-(3,4-dimethylphenyl)-N-[(3,4,5-trimethoxyphenyl)methyl]imidazo[1,2-b]pyridazin-6-amine, 3-(1,3-benzodioxol-5-yl)-6-(3-fluorophenyl)imidazo[1,2-b]pyridazine, N-[3-[3-(4-pyridyl)imidazo[1,2-b]pyridazin-6-yl]phenyl]methanesulfonamide, [4-[3-(3-pyridyl)imidazo[1,2-b]pyridazin-6-yl]phenyl]methanol, 6-(3-furyl)-3-(3-pyridyl)imidazo[1,2-b]pyridazine, 3-(3-pyridyl)-6-(2-thienyl)imidazo[1,2-b]pyridazine, N-[3-[6-(3-pyridyl)imidazo[1,2-b]pyridazin-3-yl]phenyl]acetamide, N-[3-[6-(3-acetylphenyl)imidazo[1,2-b]pyridazin-3-yl]phenyl]acetamide, N-[3-[6-[(3,4-difluorophenyl)methyl]imidazo[1,2-b]pyridazin-3-yl]phenyl]acetamide, 3-[3-(3-acetamidophenyl)imidazo[1,2-b]pyridazin-6-yl]-N-methyl-benzamide, 3-(3-chloro-4-fluoro-phenyl)-6-(2-methoxyphenyl)imidazo[1,2-b]pyridazine, 3-(3-chloro-4-fluoro-phenyl)-6-(3,4,5-trimethoxyphenyl)imidazo[1,2-b]pyridazine, 6-(2-methoxyphenyl)-3-[3-(trifluoromethoxy)phenyl]imidazo[1,2-b]pyridazine, N-(2-dimethylaminoethyl)-3-[3-[3-(trifluoromethoxy)phenyl]imidazo[1,2-b]pyridazin-6-yl]benzamide, 4-[3-[3-(trifluoromethoxy)phenyl]imidazo[1,2-b]pyridazin-6-yl]benzamide, 3-(4-methyl-2-thienyl)-N-[(3,4,5-trimethoxyphenyl)methyl]imidazo[1,2-b]pyridazin-6-amine, 6-benzyl-3-(4-methylsulfonylphenyl)imidazo[1,2-b]pyridazine, 3-[6-(3-chlorophenyl)imidazo[1,2-b]pyridazin-3-yl]-N-(2-dimethylaminoethyl)benzamide, N-(2-dimethylaminoethyl)-3-[6-[3-(hydroxymethyl)phenyl]imidazo[1,2-b]pyridazin-3-yl]benzamide, 6-[(4-fluorophenyl)methyl]-3-(5-methoxy-3-pyridyl)imidazo[1,2-b]pyridazine, 3-[3-(3-chlorophenyl)imidazo[1,2-b]pyridazin-6-yl]aniline, 3-(3-chlorophenyl)-6-(3,4-dimethoxyphenyl)imidazo[1,2-b]pyridazine, 3-(3-chlorophenyl)-6-(4-methoxy-2-methyl-phenyl)imidazo[1,2-b]pyridazine, 3-(3-chlorophenyl)-6-(3-methoxyphenyl)imidazo[1,2-b]pyridazine, 3-[6-(4-fluorophenyl)imidazo[1,2-b]pyridazin-3-yl]phenol, 3-[6-(5-quinolyl)imidazo[1,2-b]pyridazin-3-yl]phenol, [4-[6-(4-dimethylaminophenyl)imidazo[1,2-b]pyridazin-3-yl]phenyl]methanol, [4-(6-pyrimidin-5-ylimidazo[1,2-b]pyridazin-3-yl)phenyl]methanol, [4-[6-(1-methylpyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]phenyl]methanol, N-(2-hydroxyethyl)-3-[3-[3-(hydroxymethyl)phenyl]imidazo[1,2-b]pyridazin-6-yl]benzamide, [3-[6-(3-phenoxyphenyl)imidazo[1,2-b]pyridazin-3-yl]phenyl]methanol, 6-(4-pyridyl)-3-[3-(trifluoromethyl)phenyl]imidazo[1,2-b]pyridazine, 3-[3-[3-(trifluoromethyl)phenyl]imidazo[1,2-b]pyridazin-6-yl]phenol, 6-cyclopropyl-3-[3-(trifluoromethyl)phenyl]imidazo[1,2-b]pyridazine, 3-(3-fluorophenyl)-6-[(4-fluorophenyl)methyl]imidazo[1,2-b]pyridazine, 2-methoxy-4-[6-[3-(trifluoromethoxy)phenyl]imidazo[1,2-b]pyridazin-3-yl]phenol, 3-[3-(dimethylamino)phenyl]-N-(2-furylmethyl)imidazo[1,2-b]pyridazin-6-amine, 4-[6-(2-furylmethylamino)imidazo[1,2-b]pyridazin-3-yl]benzoic acid, N-[3-[3-(3-furyl)imidazo[1,2-b]pyridazin-6-yl]phenyl]acetamide, 3-[3-(3-furyl)imidazo[1,2-b]pyridazin-6-yl]benzoic acid, 3-(3-furyl)-6-(5-methoxy-3-pyridyl)imidazo[1,2-b]pyridazine, N-[4[(3-furyl)imidazo[1,2-b]pyridazin-6-yl]phenyl]acetamide, 4-[6-[(3,4-difluorophenyl)methyl]imidazo[1,2-b]pyridazin-3-yl]benzamide, 4-[6-(m-tolylmethyl)imidazo[1,2-b]pyridazin-3-yl]benzamide, N-[4-[6-(4-morpholinophenyl)imidazo[1,2-b]pyridazin-3-yl]phenyl]acetamide, N-[4-[6-(1,3-benzodioxol-5-yl)imidazo[1,2-b]pyridazin-3-yl]phenyl]acetamide, N-[4-[6-(4-methylsulfonylphenyl)imidazo[1,2-b]pyridazin-3-yl]phenyl]acetamide, 6-benzyl-3-pyrimidin-5-yl-imidazo[1,2-b]pyridazine, 6-[(4-fluorophenyl)methyl]-3-(4-methoxy-2-methyl-phenyl)imidazo[1,2-b]pyridazine, 6-[(4-fluorophenyl)methyl]-3-(3-phenoxyphenyl)imidazo[1,2-b]pyridazine, 1-[3-[6-(6-amino-3-pyridyl)imidazo[1,2-b]pyridazin-3-yl]phenyl]ethanone, 3-[3,5-bis(trifluoromethyl)phenyl]-N-(2-thienylmethyl)imidazo[1,2-b]pyridazin-6-amine, N,N-dimethyl-3-[3-(2-thienyl)imidazo[1,2-b]pyridazin-6-yl]aniline, 6-(3-chloro-4-fluoro-phenyl)-3-(2-thienyl)imidazo[1,2-b]pyridazine, 2-methoxy-4-[3-(2-thienyl)imidazo[1,2-b]pyridazin-6-yl]phenol, 6-(2-chlorophenyl)-3-(2-thienyl)imidazo[1,2-b]pyridazine, N-[3-[6-[(4-fluorophenyl)methyl]imidazo[1,2-b]pyridazin-3-yl]phenyl]methanesulfonamide, 3-(1-methylpyrazol-4-yl)-6-(m-tolylmethyl)imidazo[1,2-b]pyridazine, 5-(6-benzylimidazo[1,2-b]pyridazin-3-yl)pyridin-2-amine, (4Z)-4-[dimethylamino(imidazo[1,2-b]pyridazin-3-yl)methylene]-2-phenyl-oxazol-5-one, 3-(3-bromophenyl)-N-(2-thienylmethyl)imidazo[1,2-b]pyridazin-6-amine, 6-(1,3-benzodioxol-5-yl)-3-phenyl-[1,2,4]triazolo[4,3-a]pyridine, N-[3-(3-phenyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)phenyl]acetamide, 6-(4-methoxy-2-methyl-phenyl)-3-phenyl-[1,2,4]triazolo[4,3-a]pyridine, 3-phenyl-6-[2-(2-pyridyl)ethynyl]-[1,2,4]triazolo[4,3-a]pyridine, N,N-dimethyl-3-(3-phenyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)prop-2-yn-1-amine, N-[3-(3-phenyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)phenyl]methanesulfonamide, 3-(1,3-benzodioxol-5-yl)-6-(3-chlorophenyl)-[1,2,4]triazolo[4,3-a]pyridine, 3-(1,3-benzodioxol-5-yl)-6-(3-furyl)-[1,2,4]triazolo[4,3-a]pyridin, 3-(1,3-benzodioxol-5-yl)-6-[2-(3-methylimidazol-4-yl)ethynyl]-[1,2,4]triazolo[4,3-a]pyridine, 3-[3-(1,3-benzodioxol-5-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl]prop-2-yn-1-ol, 3-(1,3-benzodioxol-5-yl)-6-(1-methylpyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridine, 3-[3-(1,3-benzodioxol-5-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl]-N-methyl-benzamide, 4-[4-[3-(4-pyridyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl]phenyl]morpholine, 6-(3,4-dimethoxyphenyl)-3-(4-pyridyl)-[1,2,4]triazolo[4,3-a]pyridine, 3-(4-pyridyl)-6-[3-(trifluoromethoxy)phenyl]-[1,2,4]triazolo[4,3-a]pyridine, [4-[3-(4-pyridyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl]phenyl]methanol, 3-(4-pyridyl)-6-[2-[3-(trifluoromethyl)phenyl]ethynyl]-[1,2,4]triazolo[4,3-a]pyridine, 6-(3-phenoxyphenyl)-3-(4-pyridyl)-[1,2,4]triazolo[4,3-a]pyridine, N,N-dimethyl-4-[3-(3-pyridyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl]aniline, 6-(3-isopropylphenyl)-3-(3-pyridyl)-[1,2,4]triazolo[4,3-a]pyridine, 6-(2-chlorophenyl)-3-(3-pyridyl)-[1,2,4]triazolo[4,3-a]pyridine, 3-[3-(3,4-dimethoxyphenyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl]-N,N-dimethyl-aniline, 3-(3,4-dimethoxyphenyl)-6-(4-methylsulfonylphenyl)-[1,2,4]triazolo[4,3-a]pyridine, 3-(3,4-dimethoxyphenyl)-6-(3-fluorophenyl)-[1,2,4]triazolo[4,3-a]pyridine, 3-[3-(3,4-dimethoxyphenyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl]-N,N-dimethyl-benzamide, 3-(3,4-dimethoxyphenyl)-6-[2-(3-pyridyl)ethynyl]-[1,2,4]triazolo[4,3-a]pyridine, 3-(3,4-dimethoxyphenyl)-6-[2-(4-pyridyl)ethynyl]-[1,2,4]triazolo[4,3-a]pyridine, 3-(3,4-dimethoxyphenyl)-6-(2-thienyl)-[1,2,4]triazolo[4,3-a]pyridine, 6-(5-methoxy-3-pyridyl)-3-[3-(trifluoromethoxy)phenyl]-[1,2,4]triazolo[4,3-a]pyridine, 6-(3-methylsulfonylphenyl)-3-[3-(trifluoromethoxy)phenyl]-[1,2,4]triazolo[4,3-a]pyridine, 6-[2-(3-methoxyphenyl)ethynyl]-3-[3-(trifluoromethoxy)phenyl]-[1,2,4]triazolo[4,3-a]pyridine, 6-(2-thienyl)-3-[3-(trifluoromethoxy)phenyl]-[1,2,4]triazolo[4,3-a]pyridine, 6-(2-phenylethynyl)-3-[3-(trifluoromethoxy)phenyl]-[1,2,4]triazolo[4,3-a]pyridine, 3-[3-(3-chlorophenyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl]aniline, 6-(1,3-benzodioxol-5-yl)-3-(3-chlorophenyl)-[1,2,4]triazolo[4,3-a]pyridine, 3-(3-chlorophenyl)-6-(4-pyridyl)-[1,2,4]triazolo[4,3-a]pyridine, 3-(3-chlorophenyl)-6-(3-pyridyl)-[1,2,4]triazolo[4,3-a]pyridine, 3-(3-chlorophenyl)-6-(3-furyl)-[1,2,4]triazolo[4,3-a]pyridine, N-[4-[3-(3-chlorophenyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl]phenyl]acetamide, 3-(3-chlorophenyl)-6-pyrimidin-5-yl-[1,2,4]triazolo[4,3-a]pyridin, 3-(3-chlorophenyl)-6-pyrimidin-2-yl-[1,2,4]triazolo[4,3-a]pyridine, 4-[3-(3-chlorophenyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl]isoquinoline, 4-[3-(3-hydroxyphenyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl]benzonitrile, 3-[6-(4-isopropylphenyl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl]phenol, 3-[6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl]phenol, 3-[6-(5-quinolyl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl]phenol, 3-[3-(trifluoromethyl)phenyl]-6-(3,4,5-trimethoxyphenyl)-[1,2,4]triazolo[4,3-a]pyridine, N-[3-(dimethylamino)propyl]-4-[3-[3-(trifluoromethyl)phenyl]-[1,2,4]triazolo[4,3-a]pyridin-6-yl]benzamide, morpholino-[4-[3-[3-(trifluoromethyl)phenyl]-[1,2,4]triazolo[4,3-a]pyridin-6-yl]phenyl]methanone, N,N-dimethyl-4-[3-[3-(trifluoromethyl)phenyl]-[1,2,4]triazolo[4,3-a]pyridin-6-yl]benzamide, 5-[3-[3-(trifluoromethyl)phenyl]-[1,2,4]triazolo[4,3-a]pyridin-6-yl]pyridin-2-amine, 2-methoxy-4-[6-[4-(4-methylpiperazin-1-yl)phenyl]-[1,2,4]triazolo[4,3-a]pyridin-3-yl]phenol, 2-methoxy-4-[6-(6-methoxy-3-pyridyl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl]phenol, 4-[6-(3-fluorophenyl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl]-2-methoxy-phenol, 2-methoxy-4-[6-(o-tolyl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl]phenol, 3-(3-furyl)-6-(3,4,5-trimethoxyphenyl)-[1,2,4]triazolo[4,3-a]pyridine, 3-(3-furyl)-6-(4-methoxyphenyl)-[1,2,4]triazolo[4,3-a]pyridine, 3-(3-furyl)-6-(2-thienyl)-[1,2,4]triazolo[4,3-a]pyridine, 3-[6-(2-pyridyl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl]benzonitrile, 6-(3,4-dimethoxyphenyl)-3-(o-tolyl)-[1,2,4]triazolo[4,3-a]pyridine, N-(2-hydroxyethyl)-3-[3-(o-tolyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl]benzamide, 4-[3-(o-tolyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl]benzamide, 4-[4-(3-thiazol-4-yl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)phenyl]morpholine, N,N-dimethyl-3-(3-thiazol-4-yl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)aniline, 4-[6-(3-chloro-4-fluoro-phenyl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl]thiazole, 4-[6-(1H-indol-5-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl]thiazole, 3-(3-thiazol-4-yl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)benzamide, 4-[6-(4-methoxy-2-methyl-phenyl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl]thiazole, 4-[3-(3-thiazol-4-yl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)prop-2-ynyl]-1,4-thiazinane 1,1-dioxide, 4-[6-(2-chlorophenyl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl]thiazole, 4-[6-(3-methoxyphenyl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl]thiazole, 4-[6-(6-quinolyl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl]thiazole, 3-[4-[6-(3,4-dimethoxyphenyl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl]phenoxy]-N,N-dimethyl-propan-1-amine, 3-[4-[6-(4-chlorophenyl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl]phenoxy]-N,N-dimethyl-propan-1-amine, 4-[2-[3-[4-[3-(dimethylamino)propoxy]phenyl]-[1,2,4]triazolo[4,3-a]pyridin-6-yl]ethynyl]-N,N-dimethyl-benzamide, 3-[4-[6-[2-(3,5-dimethoxyphenyl)ethynyl]-[1,2,4]triazolo[4,3-a]pyridin-3-yl]phenoxy]-N,N-dimethyl-propan-1-amine, 4-[3-[4-[3-(dimethylamino)propoxy]phenyl]-[1,2,4]triazolo[4,3-a]pyridin-6-yl]-N-methyl-benzamide, N-[3-(3-quinoxalin-6-yl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)phenyl]acetamide, N-(2-dimethylaminoethyl)-3-(3-quinoxalin-6-yl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)benzamide, (4-methylpiperazin-1-yl)-[3-(3-quinoxalin-6-yl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)phenyl]methanone, 2-methoxy-4-(3-quinoxalin-6-yl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)phenol, 6-[6-(3-furyl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl]quinoxaline, N,N-dimethyl-3-(3-quinoxalin-6-yl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)benzamide, 3-[3-(2-pyridyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl]phenol, [3-[3-(2-pyridyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl]phenyl]methanol, 6-(3-methylsulfonylphenyl)-3-(2-pyridyl)-[1,2,4]triazolo[4,3-a]pyridine, N-[6-(2,3-dichlorophenyl)imidazo[1,2-a]pyrazin-3-yl]-2-(2-methoxyphenyl)acetamide, N-[6-(4-isopropylphenyl)imidazo[1,2-a]pyrazin-3-yl]-2-(2-methoxyphenyl)acetamide, N-[6-[2-(dimethylaminomethyl)phenyl]imidazo[1,2-a]pyrazin-3-yl]-2-(3-methoxyphenyl)acetamide, N-[6-[(E)-hex-1-enyl]imidazo[1,2-a]pyrazin-3-yl]-2-(3-methoxyphenyl)acetamide, N-[6-(1H-indol-5-yl)imidazo[1,2-a]pyrazin-3-yl]-2-(3-methoxyphenyl)acetamide, N-[6-[3-(hydroxymethyl)phenyl]imidazo[1,2-a]pyrazin-3-yl]-2-(3-methoxyphenyl)acetamide, 2-(3-methoxyphenyl)-N-[6-[3-(trifluoromethyl)phenyl]imidazo[1,2-a]pyrazin-3-yl]acetamide, N-[6-(4-fluorophenyl)imidazo[1,2-a]pyrazin-3-yl]-2-(3-methoxyphenyl)acetamide, N-[6-(3-furyl)imidazo[1,2-a]pyrazin-3-yl]-2-(3-methoxyphenyl)acetamide, 2-(3-methoxyphenyl)-N-[6-(4-phenoxyphenyl)imidazo[1,2-a]pyrazin-3-yl]acetamide, 2-(3-methoxyphenyl)-N-[6-(2-thienyl)imidazo[1,2-a]pyrazin-3-yl]acetamide, 2-(3-methoxyphenyl)-N-[6-(1-methylpyrazol-4-yl)imidazo[1,2-a]pyrazin-3-yl]acetamide, N-[6-[(E)-hex-1-enyl]imidazo[1,2-a]pyrazin-3-yl]pyridine-4-carboxamide, N-[6-(3-thienyl)imidazo[1,2-a]pyrazin-3-yl]thiophene-2-carboxamide, N-[6-(4-isopropylphenyl)imidazo[1,2-a]pyrazin-3-yl]acetamide, N-[6-[3-(2-dimethylaminoethylcarbamoyl)phenyl]imidazo[1,2-a]pyrazin-3-yl]furan-2-carboxamide, N-[6-(1-benzylpyrazol-4-yl)imidazo[1,2-a]pyrazin-3-yl]-2-methyl-propanamide, N-[6-(2-methoxyphenyl)imidazo[1,2-a]pyrazin-3-yl]benzamide, N-[6-[3-(dimethylamino)phenyl]imidazo[1,2-a]pyrazin-3-yl]benzamide, N-[6-(4-aminophenyl)imidazo[1,2-a]pyrazin-3-yl]benzamide, N-[6-(1,3-benzodioxol-5-yl)imidazo[1,2-a]pyrazin-3-yl]-2-phenyl-propanamide, N-[6-(3-nitrophenyl)imidazo[1,2-a]pyrazin-3-yl]-2-phenyl-propanamide, 2-(o-tolyl)-N-[6-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-3-yl]acetamide, N-[6-(1-benzylpyrazol-4-yl)imidazol[1,2-a]pyrazin-3-yl]cyclobutanecarboxamide, N-[6-(3-acetylphenyl)imidazo[1,2-a]pyrazin-3-yl]-2-cyclopropyl-acetamide, N-[6-(2-naphthyl)imidazo[1,2-a]pyrazin-3-yl]tetrahydrofuran-3-carboxamide, N-[6-(4-methoxyphenyl)imidazo[1,2-a]pyrazin-3-yl]tetrahydrofuran-3-carboxamide, N-[6-(3-aminophenyl)imidazo[1,2-a]pyrazin-3-yl]-2-(3,4-difluorophenyl)acetamide, N-[6-(2-fluorophenyl)imidazo[1,2-a]pyrazin-3-yl]-2-(3-thienyl)acetamide, N-[6-(3-methoxyphenyl)imidazo[1,2-a]pyrazin-3-yl]-2-(3-thienyl)acetamide, N-[6-(2,4-dimethoxyphenyl)imidazo[1,2-a]pyrazin-3-yl]-2-(3-thienyl)acetamide, 4-[6-[6-[3-(dimethylamino)propoxy]-3-pyridyl]imidazo[1,2-a]pyrazin-3-yl]-N,N-dimethyl-aniline, 5-[3-(4-dimethylaminophenyl)imidazo[1,2-a]pyrazin-6-yl]-N-(2-morpholinoethyl)pyridin-2-amine, 2-[3-(4-dimethylaminophenyl)imidazo[1,2-a]pyrazin-6-yl]-N,N-dimethyl-aniline, 4-[3-(4-dimethylaminophenyl)imidazo[1,2-a]pyrazin-6-yl]phenol, 4-[3-(4-dimethylaminophenyl)imidazo[1,2-a]pyrazin-6-yl]-N-[3-(dimethylamino)propyl]benzamide, 3-[3-(4-dimethylaminophenyl)imidazo[1,2-a]pyrazin-6-yl]-N-(2-hydroxyethyl)benzamide, [4-[3-(4-dimethylaminophenyl)imidazo[1,2-a]pyrazin-6-yl]phenyl]methanol, 4-[6-(6-methoxy-3-pyridyl)imidazo[1,2-a]pyrazin-3-yl]-N,N-dimethyl-aniline, N-(2-dimethylaminoethyl)-4-[3-(4-dimethylaminophenyl)imidazo[1,2-a]pyrazin-6-yl]benzamide, 4-[3-(4-dimethylaminophenyl)imidazo[1,2-a]pyrazin-6-yl]-N-(2-hydroxyethyl)benzamide, [4-[3-(4-dimethylaminophenyl)imidazo[1,2-a]pyrazin-6-yl]phenyl]-morpholino-methanone, 3-[3-(4-dimethyl aminophenyl)imidazo[1,2-a]pyrazin-6-yl]benzamide, 3-[3-(4-dimethylaminophenyl)imidazo[1,2-a]pyrazin-6-yl]-N,N-dimethyl-benzamide, 4-[6-(2-chlorophenyl)imidazo[1,2-a]pyrazin-3-yl]-N,N-dimethyl-aniline, N-[3-[3-(4-dimethylaminophenyl)imidazo[1,2-a]pyrazin-6-yl]phenyl]methanesulfonamide, 3-phenyl-6-(3-thienyl)imidazo[1,2-a]pyrazine, 6-(3-fluorophenyl)-3-phenyl-imidazo[1,2-a]pyrazine, 3-phenyl-6-(2-thienyl)imidazo[1,2-a]pyrazine, N-cyclopropyl-4-(3-phenylimidazo[1,2-a]pyrazin-6-yl)benzamide, 3-(1,3-benzodioxol-5-yl)-6-phenyl-imidazo[1,2-a]pyrazine, 3-(1,3-benzodioxol-5-yl)-6-(3-thienyl)imidazo[1,2-a]pyrazine, 3-(1,3-benzodioxol-5-yl)-6-(3-ethoxyphenyl)imidazo[1,2-a]pyrazine, 3-(1,3-benzodioxol-5-yl)-6-(3-chlorophenyl)imidazo[1,2-a]pyrazine, 3-(1,3-benzodioxol-5-yl)-6-(3-fluorophenyl)imidazo[1,2-a]pyrazine, 3-(1,3-benzodioxol-5-yl)-6-(o-tolyl)imidazo[1,2-a]pyrazine, 3-(1,3-benzodioxol-5-yl)-6-(2-thienyl)imidazo[1,2-a]pyrazine, 3-(1,3-benzodioxol-5-yl)-6-(1-benzylpyrazol-4-yl)imidazo[1,2-a]pyrazine, 3-(1,3-benzodioxol-5-yl)-6-(3,5-dimethoxyphenyl)imidazo[1,2-a]pyrazine, 5-[3-(1,3-benzodioxol-5-yl)imidazo[1,2-a]pyrazin-6-yl]pyridin-2-amine, 3-(1,3-benzodioxol-5-yl)-6-(3-isopropoxyphenyl)imidazo[1,2-a]pyrazine, 6-(2-phenoxyphenyl)-3-(4-pyridyl)imidazo[1,2-a]pyrazine, 2,6-dimethyl-4-[3-(4-pyridyl)imidazo[1,2-a]pyrazin-6-yl]phenol, morpholino-[4-[3-(4-pyridyl)imidazo[1,2-a]pyrazin-6-yl]phenyl]methanone, 3-(4-pyridyl)-6-(2-thienyl) imidazo[1,2-a]pyrazine, 4-[4-[3-(3-pyridyl) imidazo[1,2-a]pyrazin-6-yl]phenyl]morpholine, 6-(benzothiophen-2-yl)-3-(3-pyridyl)imidazo[1,2-a]pyrazine, 6-(4-methylsulfanylphenyl)-3-(3-pyridyl)imidazo[1,2-a]pyrazine, N-[3-[3-(3-pyridyl)imidazo[1,2-a]pyrazin-6-yl]phenyl]methanesulfonamide, 6-(2-furyl)-3-(3-thienyl)imidazo[1,2-a]pyrazine, 6-(3-chloro-4-fluoro-phenyl)-3-(3-thienyl)imidazo[1,2-a]pyrazine, N-(2-hydroxyethyl)-4-[3-(3-thienyl)imidazo[1,2-a]pyrazin-6-yl]benzamide, 6-(2-thienyl)-3-(3-thienyl)imidazo[1,2-a]pyrazine, 6-(3,5-dimethoxyphenyl)-3-(3-thienyl)imidazo[1,2-a]pyrazine, 4-[6-(4-chlorophenyl)imidazo[1,2-a]pyrazin-3-yl]phenol, 4-[6-[4-(4-isopropylpiperazin-1-yl)phenyl]imidazo[1,2-a]pyrazin-3-yl]phenol, N-cyclopropyl-4-[3-(4-hydroxyphenyl)imidazo[1,2-a]pyrazin-6-yl]benzamide, 4-[6-(1-methylpyrazol-4-yl)imidazo[1,2-a]pyrazin-3-yl]phenol, 3-[4-[6-(3-ethoxyphenyl)imidazo[1,2-a]pyrazin-3-yl]phenyl]propanoic acid, 3-[4-[6-(3-chlorophenyl)imidazo[1,2-a]pyrazin-3-yl]phenyl]propanoic acid, 3-[4-[6-(o-tolyl)imidazo[1,2-a]pyrazin-3-yl]phenyl]propanoic acid, 3-[4-[6-(2-chlorophenyl)imidazo[1,2-a]pyrazin-3-yl]phenyl]propanoic acid, 3-[4-[6-(2-thienyl)imidazo[1,2-a]pyrazin-3-yl]phenyl]propanoic acid, 3-[4-[6-[2-(hydroxymethyl)phenyl]imidazo[1,2-a]pyrazin-3-yl]phenyl]propanoic acid, 3-[4-[6-(2,3-dimethylphenyl)imidazo[1,2-a]pyrazin-3-yl]phenyl]propanoic acid, 4-(6-phenylimidazo[1,2-a]pyrazin-3-yl)benzonitrile, 4-[6-(3-thienyl)imidazo[1,2-a]pyrazin-3-yl]benzonitrile, 4-[6-(4-chlorophenyl)imidazo[1,2-a]pyrazin-3-yl]benzonitrile, 4-[6-[4-(hydroxymethyl)phenyl]imidazo[1,2-a]pyrazin-3-yl]benzonitrile, 4-[6-(2-thienyl)imidazo[1,2-a]pyrazin-3-yl]benzonitrile, 6-[6-(4-methylpiperazin-1-yl)-3-pyridyl]-3-(3,4,5-trimethoxyphenyl)imidazo[1,2-a]pyrazine, 3-[6-[6-[3-(dimethylamino)propoxy]-3-pyridyl]imidazo[1,2-a]pyrazin-3-yl]-N,N-dimethyl-aniline, N,N-dimethyl-3-[6-(4-pyridyl)imidazo[1,2-a]pyrazin-3-yl]aniline, N,N-dimethyl-3-[6-(3-thienyl)imidazo[1,2-a]pyrazin-3-yl]aniline, [4-[3-[3-(dimethylamino)phenyl]imidazo[1,2-a]pyrazin-6-yl]phenyl]methanol, N,N-dimethyl-3-[6-(2-thienyl)imidazo[1,2-a]pyrazin-3-yl]aniline, 3-[6-(3,5-dimethoxyphenyl)imidazo[1,2-a]pyrazin-3-yl]-N,N-dimethyl-aniline, 3-(4-chlorophenyl)-6-(4-pyridyl)imidazo[1,2-a]pyrazine, 3-(4-chlorophenyl)-6-(3-thienyl)imidazo[1,2-a]pyrazine, 3-(4-chlorophenyl)-6-(2-thienyl)imidazo[1,2-a]pyrazine, N-[3-[3-(3-chloro-4-fluoro-phenyl)imidazo[1,2-a]pyrazin-6-yl]phenyl]acetamide, 3-(3-chloro-4-fluoro-phenyl)-6-(2-furyl)imidazo[1,2-a]pyrazine, 6-(3-pyridyl)-3-[3-(trifluoromethoxy)phenyl]imidazo[1,2-a]pyrazine, N-(2-hydroxyethyl)-3-[3-[3-(trifluoromethoxy)phenyl]imidazo[1,2-a]pyrazin-6-yl]benzamide, (4-methylpiperazin-1-yl)-[3-[6-(2-phenoxyphenyl)imidazo[1,2-a]pyrazin-3-yl]phenyl]methanone, [3-[6-(1,3-benzodioxol-5-yl)imidazo[1,2-a]pyrazin-3-yl]phenyl]-(4-methylpiperazin-1-yl)methanone, (4-methylpiperazin-1-yl)-[3-[6-[4-(trifluoromethoxy)phenyl]imidazo[1,2-a]pyrazin-3-yl]phenyl]methanone, [3-[6-(3-chlorophenyl)imidazo[1,2-a]pyrazin-3-yl]phenyl]-(4-methylpiperazin-1-yl)methanone, [3-[6-(1-methylindol-5-yl)imidazo[1,2-a]pyrazin-3-yl]phenyl]-(4-methylpiperazin-1-yl)methanone, [3-[6-[4-(anilinomethyl)phenyl]imidazo[1,2-a]pyrazin-3-yl]phenyl]-(4-methylpiperazin-1-yl)methanone, [4-[3-(3-chlorophenyl)imidazo[1,2-a]pyrazin-6-yl]phenyl]methanol, [4-[3-(4-methoxyphenyl)imidazo[1,2-a]pyrazin-6-yl]phenyl]methanol, 3-(4-methoxyphenyl)-6-(2-thienyl)imidazo[1,2-a]pyrazine, 5-[3-(4-methoxyphenyl)imidazo[1,2-a]pyrazin-6-yl]pyridin-2-amine, 3-[6-(benzothiophen-2-yl)imidazo[1,2-a]pyrazin-3-yl]phenol, 3-[6-(4-chlorophenyl)imidazo[1,2-a]pyrazin-3-yl]phenol, 3-[6-[(E)-styryl]imidazo[1,2-a]pyrazin-3-yl]phenol, 3-[6-[4-(4-methylpiperazin-1-yl)phenyl]imidazo[1,2-a]pyrazin-3-yl]phenol, 3-[6-(3-chlorophenyl)imidazo[1,2-a]pyrazin-3-yl]phenol, 3-[6-(6-methoxy-3-pyridyl)imidazo[1,2-a]pyrazin-3-yl]phenol, 3-[6-(2-thienyl)imidazo[1,2-a]pyrazin-3-yl]phenol, 3-[6-(3,5-dimethoxyphenyl)imidazo[1,2-a]pyrazin-3-yl]phenol, 3-[6-(2-fluoro-3-methoxy-phenyl)imidazo[1,2-a]pyrazin-3-yl]phenol, [4-[6-(2-furyl)imidazo[1,2-a]pyrazin-3-yl]phenyl]methanol, [4-[6-(2,4-dichlorophenyl)imidazo[1,2-a]pyrazin-3-yl]phenyl]methanol, N-cyclopentyl-4-[3-[4-(hydroxymethyl)phenyl]imidazo[1,2-a]pyrazin-6-yl]benzamide, [3-(6-phenylimidazo[1,2-a]pyrazin-3-yl)phenyl]methanol, [3-[6-(4-methylsulfanylphenyl)imidazo[1,2-a]pyrazin-3-yl]phenyl]methanol, [3-[6-(3-ethoxyphenyl)imidazo[1,2-a]pyrazin-3-yl]phenyl]methanol, [3-[6-(2-thienyl)imidazo[1,2-a]pyrazin-3-yl]phenyl]methanol, [3-[6-(3-isopropoxyphenyl)imidazo[1,2-a]pyrazin-3-yl]phenyl]methanol, 3-(6-methoxy-3-pyridyl)-6-[4-(4-methylpiperazin-1-yl)phenyl]imidazo[1,2-a]pyrazine, 3,6-bis(6-methoxy-3-pyridyl)imidazo[1,2-a]pyrazine, 3-[3-(6-methoxy-3-pyridyl)imidazo[1,2-a]pyrazin-6-yl]benzamide, 3-[3-(3-fluorophenyl)imidazo[1,2-a]pyrazin-6-yl]aniline, 3-(3-fluorophenyl)-6-phenyl-imidazo[1,2-a]pyrazine, 6-(1,3-benzodioxol-5-yl)-3-(3-fluorophenyl)imidazo[1,2-a]pyrazine, 3-(3-fluorophenyl)-6-(4-piperazin-1-ylphenyl)imidazo[1,2-a]pyrazine, 6-(4-chlorophenyl)-3-(3-fluorophenyl)imidazo[1,2-a]pyrazine, [4-[3-(3-fluorophenyl)imidazo[1,2-a]pyrazin-6-yl]phenyl]methanol, 3-(3-fluorophenyl)-6-(2-thienyl)imidazo[1,2-a]pyrazine, 4-[6-[6-[3-(dimethylamino)propoxy]-3-pyridyl]imidazo[1,2-a]pyrazin-3-yl]-2-methoxy-phenol, 2-methoxy-4-[6-[6-(2-morpholinoethylamino)-3-pyridyl]imidazo[1,2-a]pyrazin-3-yl]phenol, 2-methoxy-4-[6-[6-(4-methylpiperazin-1-yl)-3-pyridyl]imidazo[1,2-a]pyrazin-3-yl]phenol, 4-[6-(1,3-benzodioxol-5-yl)imidazo[1,2-a]pyrazin-3-yl]-2-methoxy-phenol, 4-[6-(3-ethoxyphenyl)imidazo[1,2-a]pyrazin-3-yl]-2-methoxy-phenol, 4-[6-(6-amino-3-pyridyl) imidazo[1,2-a]pyrazin-3-yl]-2-methoxy-phenol, 2-methoxy-4-[6-(1-methylpyrazol-4-yl)imidazo[1,2-a]pyrazin-3-yl]phenol, N-[3-(dimethylamino)propyl]-4-[3-(1-methylindol-5-yl)imidazo[1,2-a]pyrazin-6-yl]benzamide, N-(2-hydroxyethyl)-3-[3-(1-methylindol-5-yl)imidazo[1,2-a]pyrazin-6-yl]benzamide, 2-methoxy-4-[3-(1-methylindol-5-yl)imidazo[1,2-a]pyrazin-6-yl]phenol, 3-[3-(1-methylindol-5-yl)imidazo[1,2-a]pyrazin-6-yl]benzamide, (4-methylpiperazin-1-yl)-[4-[6-[(E)-styryl]imidazo[1,2-a]pyrazin-3-yl]phenyl]methanone, N-[3-[3-(4-phenoxyphenyl)imidazo[1,2-a]pyrazin-6-yl]phenyl]methanesulfonamide, 6-(3-fluorophenyl)-3-(o-tolyl)imidazo[1,2-a]pyrazine, 3-(o-tolyl)-6-(2-thienyl)imidazo[1,2-a]pyrazine, 4-[3-(2-chlorophenyl)imidazo[1,2-a]pyrazin-6-yl]-2-methoxy-phenol, 3-[3-(4-tert-butylphenyl)imidazo[1,2-a]pyrazin-6-yl]-N,N-dimethyl-benzamide, 5-[3-(4-tert-butylphenyl)imidazo[1,2-a]pyrazin-6-yl]pyridin-2-amine, 1-[3-[6-(3-pyridyl)imidazo[1,2-a]pyrazin-3-yl]phenyl]ethanone, 1-[3-[6-(3-fluorophenyl)imidazo[1,2-a]pyrazin-3-yl]phenyl]ethanone, 4-[3-(3-acetylphenyl)imidazo[1,2-a]pyrazin-6-yl]-N-(2-dimethylaminoethyl)benzamide, 1-[3-[6-(2-thienyl)imidazo[1,2-a]pyrazin-3-yl]phenyl]ethanone, N,N-dimethyl-2-[3-(2-thienyl)imidazo[1,2-a]pyrazin-6-yl]aniline, 6-(4-pyridyl)-3-(2-thienyl)imidazo[1,2-a]pyrazine, 3-(2-thienyl)-6-(3-thienyl)imidazo[1,2-a]pyrazine, 6-(benzothiophen-2-yl)-3-(2-thienyl)imidazo[1,2-a]pyrazine, 4-[3-(2-thienyl)imidazo[1,2-a]pyrazin-6-yl]phenol, 3-(2-thienyl)-6-[4-(trifluoromethoxy)phenyl]imidazo[1,2-a]pyrazine, 6-[(E)-styryl]-3-(2-thienyl)imidazo[1,2-a]pyrazine, N-(2-hydroxyethyl)-3-[3-(2-thienyl)imidazo[1,2-a]pyrazin-6-yl]benzamide, 6-(3-chlorophenyl)-3-(2-thienyl)imidazo[1,2-a]pyrazine, [4-[3-(2-thienyl)imidazo[1,2-a]pyrazin-6-yl]phenyl]methanol, N-(2-hydroxyethyl)-4-[3-(2-thienyl)imidazo[1,2-a]pyrazin-6-yl]benzamide, 3,6-bis(2-thienyl)imidazo[1,2-a]pyrazine, N-[3-[3-(2-thienyl)imidazo[1,2-a]pyrazin-6-yl]phenyl]methanesulfonamide, 6-(3,5-dimethoxyphenyl)-3-(2-thienyl)imidazo[1,2-a]pyrazine, 5-[3-(2-thienyl)imidazo[1,2-a]pyrazin-6-yl]pyridin-2-amine, 6-(3-isopropoxyphenyl)-3-(2-thienyl)imidazo[1,2-a]pyrazine, N,N-dimethyl-4-[6-[6-(4-methylpiperazin-1-yl)-3-pyridyl]imidazo[1,2-a]pyrazin-3-yl]benzamide, N,N-dimethyl-4-[6-(2-phenoxyphenyl)imidazo[1,2-a]pyrazin-3-yl]benzamide, N,N-dimethyl-4-[6-(3-thienyl)imidazo[1,2-a]pyrazin-3-yl]benzamide, 4-[6-(3-acetamidophenyl)imidazo[1,2-a]pyrazin-3-yl]-N,N-dimethyl-benzamide, N,N-dimethyl-4-[6-(1-methylindol-5-yl)imidazo[1,2-a]pyrazin-3-yl]benzamide, 4-[6-(5-acetyl-2-thienyl) imidazo[1,2-a]pyrazin-3-yl]-N-cyclopropyl-benzamide, N-cyclopropyl-4-[6-[4-(4-isopropylpiperazin-1-yl)phenyl]imidazo[1,2-a]pyrazin-3-yl]benzamide, 2-[3-(3,5-dimethoxyphenyl)imidazo[1,2-a]pyrazin-6-yl]-N,N-dimethyl-aniline, 3-(3,5-dimethoxyphenyl)-6-(3-isopropoxyphenyl)imidazo[1,2-a]pyrazine, 3-(1-methylpyrazol-4-yl)-6-(4-pyridyl)imidazo[1,2-a]pyrazine, 6-(benzothiophen-2-yl)-3-(1-methylpyrazol-4-yl)imidazo[1,2-a]pyrazine, 6-[6-(3,4,5-trimethoxyphenyl)imidazo[1,2-a]pyrazin-3-yl]quinoline, 2-methoxy-4-[3-(6-quinolyl)imidazo[1,2-a]pyrazin-6-yl]phenol, 2,6-dimethyl-4-[3-(6-quinolyl) imidazo[1,2-a]pyrazin-6-yl]phenol, 6-[6-(1-methylindol-5-yl)imidazo[1,2-a]pyrazin-3-yl]quinoline, and N-[3-[3-(6-quinolyl)imidazo[1,2-a]pyrazin-6-yl]phenyl]methanesulfonamide, 4-[3-[6-(2-thienyl)imidazo[1,2-a]pyrazin-3-yl]phenyl]morpholine, N-[3-[6-(2-thienyl)imidazo[1,2-a]pyrazin-3-yl]phenyl]methanesulfonamide, 3-(benzothiophen-2-yl)-6-(2-thienyl)imidazo[1,2-a]pyrazine, 3-[6-(2-thienyl)imidazo[1,2-a]pyrazin-3-yl]aniline, 5-[6-(2-thienyl)imidazo[1,2-a]pyrazin-3-yl]pyridin-2-amine, 3-(3-isopropoxyphenyl)-6-(2-thienyl)imidazo[1,2-a]pyrazine, 3-[4-(1-piperidyl)phenyl]-6-(2-thienyl)imidazo[1,2-a]pyrazine, (2S)-3-methyl-2-[[3-[4-(1-piperidyl)phenyl]imidazo[1,2-b]pyridazin-6-yl]amino]butan-1-ol, (2S)-2-[[3-[3-(dimethylamino)phenyl]imidazo[1,2-b]pyridazin-6-yl]amino]-3-methyl-butan-1-ol, (2S)-3-methyl-2-[[3-(3-morpholinophenyl)imidazo[1,2-b]pyridazin-6-yl]amino]butan-1-ol, (2S)-2-[[3-(6-amino-3-pyridyl)imidazo[1,2-b]pyridazin-6-yl]amino]-3-methyl-butan-1-ol, (2S)-2-[[3-(3-isopropoxyphenyl)imidazo[1,2-b]pyridazin-6-yl]amino]-3-methyl-butan-1-ol, N,N-dimethyl-3-(3-thiazol-4-ylimidazo[1,2-a]pyrazin-6-yl)aniline, 4-[3-(3-thiazol-4-ylimidazo[1,2-a]pyrazin-6-yl)phenyl]morpholine, 5-(3-thiazol-4-ylimidazo[1,2-a]pyrazin-6-yl)pyridin-2-amine, 4-[6-(3-isopropoxyphenyl)imidazo[1,2-a]pyrazin-3-yl]thiazole, N-[3-(3-thiazol-4-ylimidazo[1,2-a]pyrazin-6-yl)phenyl]methanesulfonamide, and 3-(3-thiazol-4-ylimidazo[1,2-a]pyrazin-6-yl)aniline.