Inhibitors of the activity of complex (III) of the mitochondrial electron transport chain and use thereof
AssigneeStemergie Biotechnology SA
InventorsVirginie Clement-Schatlo, Thomas Fessard, Damien Barbaras, Joana Matos, Erick Carreira
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Abstract
The present invention relates to inhibitors of the activity of Complex (III) of the mitochondrial electron transport chain and use thereof in treatment and/or prevention of cancers presenting tumor-initiating cells. The present invention further relates to pharmaceutical compositions containing said inhibitors alone or in combination with other pharmaceutically active agents, and their use as medicaments or as agrochemicals where their properties as inhibitors of the mitochondrial respiration is of benefit.
Claims13
A compound selected from the group consisting of:
- (a) 3-formamido-N-(heptadecan-9-yl)-2-hydroxybenzamide;
- (b) N-cyclopentadecyl-7-hydroxy-1H-indazole-6-carboxamide;
- (c) N-cyclopentadecyl-3-formamido-2-hydroxybenzamide;
- (d) N-cyclododecyl-3-formamido-2-hydroxybenzamide;
- (e) 3, 5-dichloro-N-cyclopentadecyl-2-hydroxybenzamide;
- (f) 3, 5-dichloro-N-decyl-2-hydroxybenzamide;
- (g) N-(3, 5-dichloro-2-hydroxyphenyl)undecanamide;
- (h) N-(4-(cyclopentadecylcarbamoyl)phenyl)-3-formamido-2-hydroxybenzamide;
- (i) N-(heptadecan-9-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-4-carboxamide;
- (j) N-(3-(1-(heptadecan-9-yl)-1H-1,2,3-triazol-4-yl)-2-hydroxyphenyl)formamide;
- (k) N-(3-(1-cyclopentadecyl-1H-1,2,3-triazol-4-yl)-2-hydroxyphenyl)formamide;
- (l) N-cyclononyl-7-hydroxy-1H-indazole-6-carboxamide;
- (m) N-cyclononyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-4-carboxamide;
- and
- (n) N-cyclopentadecyl-2-oxo-2, 3-dihydro-1H-benzo[d]imidazole-4-carboxamide, or a pharmaceutically acceptable salt or solvate of any one of (a)-(n).
Dependencies are inferred from the claim text.