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US 9,458,103 B2Granted
Compositions and methods for inhibition of cathepsins
AssigneesMateon Therapeutics, Inc., Baylor University
InventorsDavid J. Chaplin, Kishore Kumar Gaddale Devanna, Erica Parker, Kevin G. Pinney, Jiangli Song, Mary L. Trawick
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Abstract
This invention is directed to compound of Formula I and methods of using these compounds in the treatment of conditions in which modulation of a cathepsin, particularly cathepsin K or cathepsin L, will be therapeutically useful.
Claims8
A compound of formula I:
- or a solvate or pharmaceutically acceptable salt thereof, wherein
- X is C(═O);
- n is 0 or 1;
- m is 0 or 1;
- p is 0 or 1;
- R1 and R2 are hydrogen;
- R3 and R5 are independently selected from the group consisting of hydroxyl, fluoro, and chloro;
- and
- R4 is selected from the group consisting of hydroxyl, benzoyl, and halo.
6 more elements
Dependencies are inferred from the claim text.