Low molecular weight cationic lipids for oligonucleotide delivery

A lipid nanoparticle comprising a cationic lipid according Formula A:

• wherein:
• R1 and R2 are independently selected from H, (C1-C6)alkyl, heterocyclyl, and polyamine, wherein said alkyl, heterocyclyl and polyamine are optionally substituted with one to three substituents selected from R′, or R1 and R2 can be taken together with the nitrogen to which they are attached to form a monocyclic heterocycle with 4-7 members optionally containing, in addition to the nitrogen, one or two additional heteroatoms selected from N, O and S, said monocyclic heterocycle is optionally substituted with one to three substituents selected from R′;
• R3 is selected from H and (C1-C6)alkyl, said alkyl optionally substituted with one to three substituents selected from R′;
• R′ is independently selected from halogen, R″, OR″, SR″, CN, CO2R″ and CON(R″)2;
• R″ is independently selected from H and (C1-C6)alkyl, wherein said alkyl is optionally substituted with halogen and OH;
• n is 0, 1, 2, 3, 4 or 5;
• and
• L1 is selected from C3-C24 alkyl and C3-C24 alkenyl, said alkyl and alkenyl are optionally substituted with one or more substituents selected from R;
• L2 is C12-C24 alkenyl, which is optionally substituted;
• or any pharmaceutically acceptable salt or stereoisomer thereof.