Immunomodulating compositions and methods of use thereof
AssigneesWhitehead Institute, Massachusetts Institute of Technology, Trustees of Boston University, The General Hospital Corporation
InventorsIfat Rubin-Bejerano, Gerald R. Fink, Claudia Abeijon, Daniel S. Kohane, Jason E Fuller, Robert S. Langer
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Abstract
This invention is directed to β-1-6-glucans, compositions and devices comprising the same, and methods of use thereof in modulating immune responses. The β-1-6-glucans of certain embodiments of the invention are enriched for O-acetylated groups and/or conjugated to a solid support or linked to a targeting moiety.
Claims39
A composition comprising β-1-6-glucan linked to a targeting moiety, wherein the targeting moiety is selected from the group consisting of an engineered binding protein, an antibody, an antibody fragment, a nucleic acid, a peptide, and a small molecule, and wherein the targeting moiety specifically interacts with a neoplastic cell, a pre-neoplastic cell, a pathogen, or a component thereof.
The composition of claim wherein e targeting moiety is an engineered binding protein.
A composition comprising β-1-6-glucan comprising at least 4 and fewer than 50 glucose monosaccharide units linked to a targeting moiety, wherein the targeting moiety is selected from the group consisting of an engineered binding protein, an antibody, an antibody fragment, a nucleic acid, a peptide, and a small molecule, and wherein at least 95% of the dry weight of glucan contained in the composition is β-1-6-glucan.
A composition comprising soluble β-1-6-glucan linked to a targeting moiety, wherein the targeting moiety is selected from the group consisting of an engineered binding protein, an antibody, an antibody fragment, a nucleic acid, a peptide, and a small molecule, and wherein at least 95% of the dry weight of glucan contained in the composition is soluble β-1-6-glucan.
A composition comprising β-1-6-glucan comprising at least 4 and fewer than 50 glucose monosaccharide units linked to a targeting moiety, wherein the targeting moiety is selected from the group consisting of an engineered binding protein, an antibody, an antibody fragment, a nucleic acid, a peptide, and a small molecule, and wherein less than 5% of the total glucan in the composition, by weight, is β-1,3-glucan.
A composition comprising soluble β-1-6-glucan linked to a targeting moiety, wherein the targeting moiety is selected from the group consisting of an engineered binding protein, an antibody, an antibody fragment, a nucleic acid, a peptide, and a small molecule, and wherein less than 5% of the total glucan in the composition, by weight, is β-1,3-glucan.
Dependencies are inferred from the claim text.