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US 9,453,253 B2Granted
Methods of using isotopically labelled isoniazid for the diagnosis of mycobacterial infections
AssigneesStc.Unm, The Johns Hopkins University
InventorsGraham Timmins, Seong Choi, Zachary Sharp, Viorel Atudorei, Mamoudou Maiga, William Bishai
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Abstract
The present invention is directed to methods of diagnosing the presence or absence of a bacterial infection in a patient, in particular, a tuberculosis infection, by measuring exhaled, isotopically labeled nitrogen gas after administration of isotopically labeled isoniazid.
Claims8
A method for determining the presence or absence of a mycobacterial infection in the lungs of a patient comprising:
- administering to the lungs of the patient a diagnostically effective amount of 15N-labeled isoniazid and optionally, isotopically labeled urea;
- collecting one or more samples of exhaled breath from the subject;
- and
- determining an amount of 15N-labeled nitrogen gas in said samples;
- said amount indicating presence or absence of the mycobacterial infection in the lungs of the patient.
2 more elements
Dependencies are inferred from the claim text.