Polypeptide structural motifs associated with cell signaling activity
AssigneeaTyr Pharma, Inc.
InventorLeslie Ann Greene
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Abstract
Isolated polypeptides comprising or consisting essentially of specific structural motifs (e.g., three β-sheets and two α-helices) are provided, wherein the polypeptides exhibit at least one cell signaling and/or other non-canonical activity of biological relevance. Also provided are polynucleotides encoding such polypeptides, binding agents that bind such polypeptides, analogs, variants and fragments of such polypeptides, etc., as well as compositions and methods of identifying and using any of the foregoing.
Claims6
A pharmaceutical composition comprising an isolated seryl-tRNA synthetase (SerRS) polypeptide that is at least about 90% pure and consists essentially of three antiparallel β-sheets flanked at each end by an α-helix, wherein the polypeptide comprises a contiguous fragment of a human SerRS polypeptide as defined by SEQ ID NO:6, or a sequence having at least 90% sequence identity to said contiguous fragment and wherein the SeRS polypeptide is about 60 to 200 amino acid residues and exhibits a cell signaling activity.
Dependencies are inferred from the claim text.