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US 9,453,211 B2Granted
Dehalogenases, nucleic acids encoding them and methods for making and using them
AssigneeBASF Enzymes LLC
InventorsJay M. Short, Toby Richardson, Dan E. Robertson, Kevin A. Gray
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Abstract
The invention relates to haloalkane dehalogenases and to polynucleotides encoding the haloalkane dehalogenases. In addition methods of designing new dehalogenases and method of use thereof are also provided. The dehalogenases have increased activity and stability at increased pH and temperature.
Claims20
A synthetic or recombinant nucleic acid operably linked to a promoter, said nucleic acid sequence comprising:
- (a) a nucleic acid sequence having at least 97% sequence identity to at least one of SEQ ID NOS:
- 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 45, or 47;
- or
- (b) a nucleic acid sequence complementary to (a);
- or
- (c) the nucleic acid sequence of (a), wherein the nucleic acid encodes at least one polypeptide having a dehalogenase activity.
3 more elements
Dependencies are inferred from the claim text.