Formylated xanthocillin analogues as neuroprotective agents
AssigneeNeuron Biopharma, S.A.
InventorsMaria del Carmen Ramos Martin, Sonia Campoy Garcia, Javier Santos Burgos Muñoz, José Luis Adrio Fondevila, Javier Velasco Alvarez
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Abstract
Formylated xanthocillin analogs can be used in the treatment of neurodegenerative diseases. The analogs can be prepared synthetically, and at least some of the analogs can be obtained from a microorganism strain of the Penicillium chrysogenum species.
Claims10
A method for inhibiting neuronal cell death caused by oxidative stress, wherein the diseases treatable by said inhibition are selected from Alzheimer's disease, mild cognitive impairment, Huntington's disease, Parkinson's disease, Creutzfeldt-Jakob disease, amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS), as well as progeria, the method comprising:
- administering to a patient needing such treatment a therapeutically effective amount of at least a compound of formula (I):
- where:
- R1 is selected from alkyl, OH, O-alkyl, SH, S-alkyl, NH2, NH-alkyl, N(alkyl)2 and halogen,
- R2, R3 and R4 are selected independently from hydrogen, alkyl, OH, O-alkyl, SH, S-alkyl, NH2, NH-alkyl, N(alkyl)2 and halogen,
- or R1 and R2 and/or R3 and R4 form an —O-alkylene-O— group,
- or a pharmaceutically acceptable salt or solvate thereof.
Dependencies are inferred from the claim text.