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US 9,447,405 B2Granted
Regulation of specific spinal neurons regulating pain transmission via chimeric toxins
AssigneesWisconsin Alumni Research Foundation, The Regents of the University of California
InventorsEric A. Johnson, Sabine Pellett, William H. Tepp, Tony L. Yaksh, Marc Marino, Qinghao Xu
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Abstract
A chimeric toxin is disclosed comprising a peptide ligand specifically targeting neurons involved in pain processing; and a clostridial neurotoxin light chain, wherein the ligand is linked to the light chain. The methods of preparing such chimeric toxin and the method of using the chimeric toxin to regulate pain transmission are also disclosed.
Claims4
A chimeric toxin comprising
- (a) a peptide ligand specifically targeting neurons involved in pain processing;
- wherein the ligand is Substance P (SEQ ID NO:1), and
- (b) a clostridial neurotoxin light chain, wherein the light chain is botulinum toxin type A light chain,
- wherein the ligand is linked to the light chain to form a chimeric toxin, and wherein the chimeric toxin does not comprise a translocation domain.
1 more element
A pharmaceutical formulation comprising
- (a) a therapeutically effective amount of a chimeric toxin comprising
- (i) a peptide ligand specifically targeting neurons involved in pain processing, wherein the ligand is substance P (SEQ ID NO:1);
- and
- (ii) a clostridial neurotoxin light chain, wherein the light chain is type A light chain,
- wherein the ligand is linked to the light chain to form a chimeric toxin, and wherein the chimeric toxin does not comprise a translocation domain;
- and
- (b) a pharmaceutically acceptable carrier.
4 more elements
Dependencies are inferred from the claim text.