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US 9,447,089 B2Granted
Compositions and uses thereof
AssigneesPlexxikon Inc., Hoffman-La Roche Inc.
InventorsDipen Desai, Ralph Diodone, Zenaida Go, Prabha N. Ibrahim, Raman Iyer, Hans-Juergen Mair, Harpreet K. Sandhu, Navnit H. Shah, Gary Visor, Nicole Wyttenbach, Stephan Lauper, Johannes Pudewell, Frank Wierschem
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Abstract
Provided are solid dispersions, solid molecular complexes, salts and crystalline polymorphs involving propane-1-sulfonic acid {3-[5-(4-chloro-phenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide.
Claims29
A solid dispersion comprising Compound I having the formula:
- wherein Compound I is molecularly dispersed within a polymer matrix formed by hydroxypropylmethyl cellulose acetate succinate (HPMCAS) in its solid state, and wherein Compound I is substantially amorphous.
A tablet comprising a solid dispersion, wherein the solid dispersion comprises Compound I having the formula:
- wherein Compound I is molecularly dispersed within a polymer matrix formed by hydroxypropylmethyl cellulose acetate succinate (HPMCAS) in its solid state, Compound I is substantially amorphous, and the ratio of an amount by weight of Compound I within the solid dispersion to an amount by weight of HPMCAS is about 3:7.
Dependencies are inferred from the claim text.