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US 9,447,025 B2Granted
Bicyclic analgesic compounds
AssigneeKalyra Pharmaceuticals, Inc.
InventorKevin Duane Bunker
Life of this patent
Estimating the term…
Abstract
Analgesic compounds for treatment of pain or fever, comprising a bicyclopentane moiety linked to an amine, combinations of the compounds with opioid analgesic drugs, and methods for treating pain or fever by administering the compounds.
Claims8
A compound of Formula 1:
- wherein
- R1 is H, —CH3, CF3, or a substituted or unsubstituted (C2 to C5) lower alkyl;
- R2 is C(═Y)R4;
- R3 is F, D, hydroxy, (C1 to C10) alkoxy, (C1 to C30) substituted or unsubstituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, or —(C═O)L;
- R4 is CF3 or (C1 to C10) substituted or unsubstituted lower alkyl;
- Y is S or O;
- and
- —(C═O)L is a hydrolyzable prodrug ester leaving group.
5 more elements
A method for treating an individual, comprising identifying an individual in need of treatment to reduce or at least partially prevent pain or fever;
- and administering an effective amount of an opioid analgesic in conjunction with administering to the individual the compound of Formula 1:
- wherein
- R1 is H, —CH3, CF3, or a substituted or unsubstituted (C2 to C5) lower alkyl;
- R2 is H or C(═Y)R4;
- R3 is F, D, hydroxy, (C1 to C10) alkoxy, (C1 to C30) substituted or unsubstituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, or —(C═O)L;
- R4 is CF3 or (C1 to C10) substituted or unsubstituted lower alkyl;
- Y is S or O;
- and
- —(C═O)L is hydrolyzable prodrug ester leaving group.
6 more elements
Dependencies are inferred from the claim text.