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US 9,446,003 B2Granted
Prion free nanoparticle compositions and methods of making thereof
AssigneeAbraxis BioScience, LLC
InventorsNeil P. Desai, Viktor Peykov, Patrick Soon-Shiong
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Abstract
The present invention provides prion-free compositions comprising nanoparticles comprising albumin and substantially water insoluble drugs. Also provided are methods of making prion-free compositions and methods of removing prion proteins from the nanoparticle compositions. Methods of using the compositions, as well as kits useful for carrying out the methods are also provided.
Claims10
A method of removing prion proteins from a composition comprising nanoparticles comprising a substantially water insoluble pharmacologically active agent coated with albumin, wherein said method comprises:
- (a) providing a suspension of nanoparticles comprising a substantially water insoluble pharmacologically active agent coated with albumin;
- and
- (b) treating said suspension of nanoparticles provided in step (a) by passing said suspension of nanoparticles through a chromatography column, wherein the column comprises a ligand capable of binding to a prion protein,
- wherein there are no significant differences between the treated and untreated suspensions in terms of particle size and pH.
1 more element
Dependencies are inferred from the claim text.