Lipid vesicle compositions and methods of use
AssigneeMassachusetts Institute of Technology
InventorsDarrell J. Irvine, Jaehyun Moon
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Abstract
The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles comprise terminal-cysteine-bearing antigens or cysteine-modified antigens, at their surface and/or internally.
Claims27
A multilamellar lipid vesicle comprising at least one terminal-cysteine-bearing antigen, and having covalent crosslinks between lipid bilayers, wherein at least two lipid bilayers in the multilamellar lipid vesicle are covalently crosslinked to each other through headgroups that react with covalent crosslinkers to form the covalent crosslinks between lipid bilayers, and wherein the terminal-cysteine-bearing antigen is an immunostimulatory agent or an immunoinhibitory agent.
A multilamellar lipid vesicle comprising at least one terminal-cysteine-bearing antigen, and having covalent crosslinks between lipid bilayers, wherein at least two lipid bilayers in the multilamellar lipid vesicle are covalently crosslinked to each other through headgroups that react with covalent crosslinkers to form the covalent crosslinks between lipid bilayers, and wherein the terminal-cysteine-bearing antigen is a cancer antigen.
A multilamellar lipid vesicle comprising at least one terminal-cysteine-bearing antigen that is encapsulated between lipid bilayers and/or is present in the core of the vesicle and having covalent crosslinks between lipid bilayers, wherein at least two lipid bilayers in the multilamellar lipid vesicle are covalently crosslinked to each other through headgroups that react with covalent crosslinkers to form the covalent crosslinks between lipid bilayers, and wherein the terminal-cysteine-bearing antigen is an immunostimulatory agent, an immunoinhibitory agent, or a cancer antigen.
Dependencies are inferred from the claim text.