Isolated and purified strains of Chikungunya virus and polynucleotides and polypeptides sequences, diagnostic and immunogenical uses thereof
AssigneeInstitut Pasteur
InventorsPhilippe Despres, Anne-Claire Brehin, Valerie Marechal, Pierre Charneau, Philippe Souque
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Abstract
The present invention concerns wild-strains of Chikungunya virus isolated from patients exhibiting severe forms of infection and stemming from a human arbovirosis epidemy. The present invention also concerns polypeptide sequences and fragment thereof derived from their genome, the polynucleotide encoding same and their use as diagnostic products, as vaccine and/or as immunogenic compositions.
Claims17
A vector comprising a nucleotide sequence encoding a Chikungunya virus E2 protein and a heterologous nucleotide sequence regulating expression of the E2 protein, wherein the E2 protein comprises a threonine at amino acid position 489 of the Chikungunya virus E2 protein and a methionine at amino acid position 637 of the Chikungunya virus E2 protein.
Dependencies are inferred from the claim text.