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US 9,441,246 B2Granted
Adeno-parvovirus chimera with enhanced oncolytical potential
AssigneeDeutsches Krebsforschungszentrum
InventorsNazim El-Andaloussi, Antonio Marchini, Jean Rommelaere
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Abstract
Described is a chimerical adenovirus-parvovirus vector characterized in that it comprises the entire parvovirus genome inserted into a adenovirus genome, wherein: (a) the adenovirus genome is characterized by deletion of E1 and E3, and (b) the biological activity of the parvoviral protein NS, preferably NS1, is reduced or eliminated.
Claims19
A chimeric adeno-parvovirus vector characterized in that it comprises an entire parvovirus genome inserted into an adenovirus genome, wherein:
- (a) The adenovirus genome is characterized by deletion of E1 and E3;
- and
- (b) the activity of a parvovirus P4 early promoter, which regulates the expression of a nonstructural parvovirus protein (NS) is modified to repress or block the NS protein expression in a packaging cell line during chimera production but is fully functional in cancer cells with respect to the activity of a wild-type parvovirus P4 early promoter,
- wherein the parvovirus P4 early promoter is modified by inserting two tetracycline operator 2 elements between a TATA box and a NS start codon.
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Dependencies are inferred from the claim text.