Method and system for the production of cells and cell products and applications thereof

A cell culture system for the production of cells and cell derived products comprising:

• a reusable instrumentation base device incorporating hardware to support cell culture growth;
• and
• at least one disposable cell cultureware module removably attachable to said instrumentation base device, said module including a cell growth chamber and
• at least one rotary actuator valve for controlling circulation of cell culture medium through at least one elastomer medium flow circuit in said cultureware module, said at least one rotary actuator valve including a housing having an inner passage and at least one port for receiving the at least one elastomer medium flow circuit, and a valve body having first and second ends located within said inner passage of said valve housing and rotatable about a longitudinal axis within said valve housing, said valve body including a plurality of cam surfaces and angular sections along a length thereof to sequentially compress and open the at least one elastomer medium flow circuit as said valve body rotates within said valve housing, wherein said plurality of cam surfaces compresses the at least one elastomer medium flow circuit by making direct contact with a segment of the at least one elastomer medium flow circuit.