US 9,439,882 B2 · Compounds and compositions for the treatment of cancer

Abstract

New uses for phenylketone carboxylate compounds and substituted aromatic compounds of Formula I, Formula I.1, Formula I.2, Formula IA, Formula IB, Formula IC and Formula II and their pharmaceutical acceptable salts for the treatment of cancer. The use of a combination of two of these compounds is described and the use of the combination of one of these compounds with an anticancer agent such as decarbazine, doxorubicin, daunorubicin, cyclophosphamide, busulfex, busulfan, vinblastine, vincristine, bleomycin, etoposide, topotecan, irinotecan, taxotere, taxol, 5-fluorouracil, methotrexate, gemcitabine, cisplatin, carboplatin and chlorambucil.

Claims15

Dependent claims

A method for inhibiting tumor cell migration and establishment of metastasis in a subject suffering from cancer, wherein said method comprises administering to the subject a compound represented by Formula IA, or a pharmaceutically acceptable salt thereof:

wherein
R2 and R3 are independently selected from H, OH, F or Cl;
X1 is (CH2)n, wherein n is 0, 1 or 2;
and
R4 is (CH2)m1, (CH2)q1CH═CH, or CH═CH(CH2) wherein m1 is 4, 5 or 6 and q1 is 2, or 3.

2 more elements

Dependencies are inferred from the claim text.

Facts

Application

14/797,957Filed 13 Jul 2015 · continuation

Priority

27 Oct 2010

Published

US 2015/0313856 A15 Nov 2015

Granted

13 Sep 2016

Term ends

Not estimatedThe source records don’t support an estimate.

Classification18 codes

A61K 31/192
Carboxylic acids, e.g. valproic acid: having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
A61K 31/196
Having an amino group: the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
A61K 31/22
Of carboxylic acids: of acyclic acids, e.g. pravastatin
A61K 31/513
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim: having oxo groups directly attached to the heterocyclic ring, e.g. cytosine

Family

Application61/407,069Us provisional application · filed 27 Oct 2010

PCT/CA2011/001179Parent of this continuation · filed 26 Oct 2011

US 2015/0313856 A1Pre-grant publication · published 5 Nov 2015

Application13/882,355Parent of this continuation

US 9,114,118 B2Parent of this continuation

US 2013/0217645 A1Published application

US 9,439,882 B2This patent

From the US filing history. Foreign family members aren’t listed.

Compounds and compositions for the treatment of cancer

Life of this patent

Compounds and compositions for the treatment of cancer

Life of this patent

Abstract

Claims15