# US 9,435,736 B2 · System for blood separation with shielded extraction port and optical control

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- Number: US 9,435,736 B2
- Document ID: US9435736B2
- Status: Granted
- Kind: B2
- Application number: 14/014,147
- Filed: 2013-08-29
- Published: 2014-01-02
- Granted: 2016-09-06
- Earliest claimed: 2009-12-11
- Assignees: Terumo BCT, Inc.
- Applicants: Terumo BCT, Inc.
- Inventors: Jeremy P. Kolenbrander; Brian M. Holmes; Thomas J. Felt; James R. Ladtkow
- Web page: https://patentgrep.com/patent/US9435736B2

## CPC

- G01N 21/51: inside a container, e.g. in an ampoule (G01N21/53 takes precedence)
- A61M 1/36225: {with blood pumping means or components thereof}
- A61M 1/362262: {Details of incorporated reservoirs}
- A61M 1/3693: {using separation based on different densities of components, e.g. centrifuging}
- A61M 1/3696: {with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation}
- B04B 13/00: Control arrangements specially designed for centrifuges; Program control of centrifuges (control arrangements for feed, charge or discharge B04B11/00)
- A61M 1/3616: {Batch-type treatment}
- A61M 1/36222: {Details related to the interface between cassette and machine}
- A61M 1/362265: {Details of valves}
- A61M 1/362266: {Means for adding solutions or substances to the blood}
- A61M 2202/0439: White blood cells; Leucocytes
- A61M 2205/3306: Optical measuring means
- B04B 2013/006: {Interface detection or monitoring of separated components}
- G01N 2035/00495: {Centrifuges}
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}
- B04B: CENTRIFUGES (high-speed drum mills B02C19/11; domestic spin driers D06F; analysing, measuring or monitoring physical or chemical properties of samples during centrifuging, see the relevant subclasses for these procedures, e.g. G01N)

## Abstract

A centrifugal blood separation system comprising a rotor, a light source, an optical sensor, a control system, a separation vessel, and an optical cell on the separation vessel. The optical cell has a first extraction port extending radially outwardly into the optical cell, a red blood cell extraction port downstream from the first extraction port and extending into the optical cell beyond the first extraction port; and a dam between said first extraction port and said red blood cell extraction port, having an upper edge and a lower edge, wherein the first extraction port and the red cell extraction port are radially between the upper edge and the lower edge of the dam. Also, a first extraction port having a bore having a first diameter, a lumen having a second diameter smaller than the first diameter, and a frustro-conical passageway coupling the bore to the lumen.

## Claims

### Claim 1

An optical cell for a separation chamber of a density centrifuge blood processing system for separating fluid components, said optical cell being adapted to be mounted on a rotor of said blood processing system, said optical cell comprising:
an extraction chamber adapted to transmit at least a portion of an incident optical beam; and
a first extraction port extending radially outwardly into said optical cell with respect to an axis of rotation of said rotor and being adapted to transmit at least a portion of the incident optical beam, said first extraction port having
an orifice opening into said extraction chamber,
a bore for passing fluid components, said bore being adjacent said orifice of said first extraction port, said bore having a first diameter,
a lumen in fluid communication with said bore and downstream therefrom with respect to fluid flowing through said bore into said lumen, said lumen having a second diameter smaller than said first diameter of said bore, and
a frustro-conical passageway smoothly coupling said first diameter of said bore to said second diameter of said lumen.

### Claim 2

A tubing set for a density centrifuge blood processing system for separating fluid components, said tubing set comprising
a separation chamber adapted to be mounted on a rotor of said blood processing system,
an optical cell in fluid communication with said separation chamber, said optical cell comprising:
an extraction chamber adapted to transmit at least a portion of an incident optical beam; and
a first extraction port extending radially outwardly into said optical cell with respect to an axis of rotation of said rotor and being adapted to transmit at least a portion of the incident optical beam, said first extraction port having
an orifice opening into said extraction chamber,
a bore for passing fluid components, said bore being adjacent said orifice of said first extraction port, said bore having a first diameter,
a lumen in fluid communication with said bore and downstream therefrom with respect to fluid flowing through said bore into said lumen, said lumen having a second diameter smaller than said first diameter of said bore, and
a frustro-conical passageway smoothly coupling said first diameter of said bore to said second diameter of said lumen.

### Claim 3

A centrifugal blood separation system comprising
a rotor adapted to impart centrifugal force to separate blood into blood components,
a light source adapted to selectively illuminate an observation region on said rotor,
an optical sensor adapted to detect light from said light source,
a control system in electrical communication with said rotor, said light source and said optical sensor and adapted to control said rotor, light source and sensor,
a separation vessel mounted on said rotor, wherein blood may be separated into blood components,
an optical cell in fluid communication with said separation vessel, said optical cell comprising:
an extraction chamber adapted to transmit at least a portion of an incident optical beam; and
a first extraction port extending radially outwardly into said optical cell with respect to an axis of rotation of said rotor and being adapted to transmit at least a portion of the incident optical beam, said first extraction port having
an orifice opening into said extraction chamber,
a bore for passing fluid components, said bore being adjacent said orifice of said first extraction port, said bore having a first diameter,
a lumen in fluid communication with said bore and downstream therefrom with respect to fluid flowing through said bore into said lumen, said lumen having a second diameter smaller than said first diameter of said bore, and
a frustro-conical passageway smoothly coupling said first diameter of said bore to said second diameter of said lumen.