# US 9,435,730 B2 · Image information obtaining apparatus and control method for same > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 9,435,730 B2 - Document ID: US9435730B2 - Status: Granted - Kind: B2 - Application number: 13/810,802 - Filed: 2011-07-08 - Published: 2013-05-16 - Granted: 2016-09-06 - Earliest claimed: 2010-07-27 - Assignees: Canon Kabushiki Kaisha - Applicants: Hiroshi Nishihara - Inventors: Hiroshi Nishihara - Web page: https://patentgrep.com/patent/US9435730B2 ## CPC - G01N 21/1702: {with opto-acoustic detection, e.g. for gases or analysing solids} - A61B 5/0073: {by tomography, i.e. reconstruction of 3D images from 2D projections (A61B5/0066 takes precedence)} - A61B 5/0095: {by applying light and detecting acoustic waves, i.e. photoacoustic measurements} - A61B 5/14546: {for measuring analytes not otherwise provided for, e.g. ions, cytochromes} - A61B 8/587: {Calibration phantoms} - A61B 2560/0228: using calibration standards - G01N 29/06: Visualisation of the interior, e.g. acoustic microscopy {(medical or veterinary diagnosis using sonic waves A61B8/00; representation of acoustic wave distribution G01H3/125, G01H9/002; short-range imaging systems using reflection of acoustic waves G01S15/8906)} - G01N 29/0654: {Imaging} - G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q) - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract An image information obtaining apparatus having: a light source; a transducer which detects an acoustic wave and converts the acoustic wave to an electrical signal; a signal processing unit which generates image data, using the electrical signal; and a memory unit which stores a reference acoustic signal produced by the transducer detecting an acoustic wave generated when light is irradiated from the light source onto a phantom having acoustic parameters and optical parameters substantially the same as an object and converting the acoustic wave to an electrical signal, wherein the transducer produces an object acoustic signal by converting the acoustic wave, generated when light is irradiated onto an object from the light source, to an electrical signal; and the signal processing unit subtracts the reference acoustic signal from the object acoustic signal and generates image data from the signal resulting from this subtraction. ## Claims ### Claim 1 An image information obtaining apparatus, comprising: a light source; a transducer configured to convert an acoustic wave into an electrical signal; a signal processing unit configured to obtain image data, using the electrical signal; and a memory which stores a reference acoustic signal, wherein said transducer is configured to output an object acoustic signal by detecting an acoustic wave generated when an object is irradiated with light from said light source, said memory stores the reference acoustic signal which is outputted from said transducer by detection of an acoustic wave generated when a phantom, which simulates the object and is located at a position where the object is to be located, is irradiated with light from said light source, said signal processing unit is configured to: obtain an intensity of a signal corresponding to the acoustic wave generated from a surface of the object, out of the object acoustic signal; obtain an intensity of a signal corresponding to the acoustic wave generated from a surface of the phantom, out of the reference acoustic signal; obtain a correction coefficient based on a result of comparing between the intensity of the signal corresponding to the acoustic wave generated from the surface of the object and the intensity of the signal corresponding to the acoustic wave generated from the surface of the phantom; and obtain a subtraction signal between the reference acoustic signal and the object acoustic signal which are corrected by using the correction coefficient, and obtain image data using the subtraction signal. ### Claim 2 (depends on 1) The image information obtaining apparatus according to claim 1, wherein the phantom has acoustic parameters and optical parameters substantially the same as the object. ### Claim 3 (depends on 1) The image information obtaining apparatus according to claim 1, wherein a light scattering coefficient of the phantom is no less than 0.45 mm−1 and no more than 2.8 mm−1, a light absorption coefficient of the phantom is no less than 0.001 mm−1 and no more than 0.03 mm−1, and an acoustic impedance of the phantom is no less than 1.5×106 kg/m2 sec and no more than 1.6×106 kg/m2 sec. ### Claim 4 (depends on 1) The image information obtaining apparatus according to claim 1, wherein a light scattering coefficient of the phantom is no less than 0.45 mm−1 and no more than 1.2 mm−1, a light absorption coefficient of the phantom is no less than 0.005 mm−1 and no more than 0.015 mm−1, and an acoustic impedance of the phantom is no less than 1.5×106 kg/m2 sec and no more than 1.6×106 kg/m2 sec. ### Claim 5 (depends on 1) The image information obtaining apparatus according to claim 1, wherein the light source emits light in a wavelength range of no less than 700 nm and no more than 1100 nm. ### Claim 6 (depends on 1) The image information obtaining apparatus according to claim 1, wherein said signal processing unit is configured to obtain the correction coefficient such that a difference between the intensity of the signal corresponding to the acoustic wave generated from the surface of the object and the intensity of the signal corresponding to the acoustic wave generated from the surface of the phantom is reduced. ### Claim 7 (depends on 1) The image information obtaining apparatus according to claim 1, wherein said transducer is arranged on a side of an irradiated surface of the object. ### Claim 8 (depends on 7) The image information obtaining apparatus according to claim 7, further comprising an acoustic matching member which is arranged between the object and the transducer and has an acoustic impedance between that of the object and the transducer, wherein said light source irradiates the object with light through said acoustic matching member. ### Claim 9 An image information obtaining apparatus, comprising: a light source; a transducer configured to convert an acoustic wave into an electrical signal; a signal processing unit configured to obtain image data, using the electrical signal; a memory which stores reference image data, wherein said transducer is configured to output an object acoustic signal by detecting an acoustic wave generated when an object is irradiated with light from said light source, said memory stores the reference image data which is obtained based on an acoustic wave generated when a phantom, which simulates the object and is located at a position where the object is to be located, is irradiated with light from said light source, and said signal processing unit is configured to: obtain object image data using the object acoustic signal, obtain an intensity of image data corresponding to the acoustic wave generated from a surface of the object, out of the object image data; obtain an intensity of image data corresponding to the acoustic wave generated from a surface of the phantom, out of the reference image data; obtain a correction coefficient based on a result of comparing between the intensity of the image data corresponding to the acoustic wave generated from the surface of the object and the intensity of the image data corresponding to the acoustic wave generated from the surface of the phantom; and obtain a subtraction image data between the object image data and the reference image data, which are corrected by using the correction coefficient. ### Claim 10 (depends on 9) The image information obtaining apparatus according to claim 9, wherein the phantom has acoustic parameters and optical parameters substantially the same as the object. ### Claim 11 (depends on 9) The image information obtaining apparatus according to claim 9, wherein a light scattering coefficient of the phantom is no less than 0.45 mm−1 and no more than 2.8 mm−1, a light absorption coefficient of the phantom is no less than 0.001 mm−1 and no more than 0.03 mm−1, and an acoustic impedance of the phantom is no less than 1.5×106 kg/m2 sec and no more than 1.6×106 kg/m2 sec. ### Claim 12 (depends on 9) The image information obtaining apparatus according to claim 9, wherein a light scattering coefficient of the phantom is no less than 0.45 mm−1 and no more than 1.2 mm−1, a light absorption coefficient of the phantom is no less than 0.005 mm−1 and no more than 0.015 mm−1, and an acoustic impedance of the phantom is no less than 1.5×106 kg/m2 sec and no more than 1.6×106 kg/m2 sec. ### Claim 13 (depends on 9) The image information obtaining apparatus according to claim 9, wherein the light source emit light in a wavelength range of no less than 700 nm and no more than 1100 nm. ### Claim 14 (depends on 9) The image information obtaining apparatus according to claim 9, wherein said signal processing unit is configured to obtain the correction coefficient such that a difference between the intensity of the image data corresponding to the acoustic wave generated from the surface of the object and the intensity of the image data corresponding to the acoustic wave generated from the surface of the phantom is reduced. ### Claim 15 (depends on 9) The image information obtaining apparatus according to claim 9, wherein said transducer is arranged on a side of an irradiated surface of the object. ### Claim 16 (depends on 15) The image information obtaining apparatus according to claim 15, further comprising an acoustic matching member which is arranged between the object and the transducer and has an acoustic impedance between that of the object and the transducer, wherein said light source irradiates the object with light through said acoustic matching member. ### Claim 17 A control method for an image information obtaining apparatus having a light source, a transducer configured to convert an acoustic wave into an electrical signal, a memory, and a signal processing unit, wherein the memory stores a reference acoustic signal which is outputted from the transducer by detection of an acoustic wave generated when a phantom, which simulates an object and is located at a position where the object is to be located, is irradiated with light from the light source, the control method comprising: a step of irradiating the object with light from the light source; a step of detecting by the transducer an acoustic wave generated from the object which has absorbed light, and storing a signal outputted from the transducer in the memory as an object acoustic signal; a step of obtaining by the signal processing unit an intensity of a signal corresponding to the acoustic wave generated from a surface of the object, out of the object acoustic signal; a step of obtaining by the signal processing unit an intensity of a signal corresponding to the acoustic wave generated from a surface of the phantom, out of the reference acoustic signal; a step of obtaining by the signal processing unit a correction coefficient based on a result of comparing between the intensity of the signal corresponding to the acoustic wave generated from the surface of the object and the intensity of the signal corresponding to the acoustic wave generated from the surface of the phantom; a step of obtaining by the signal processing unit a subtraction signal between the reference acoustic signal and the object acoustic signal, which are corrected by using the correction coefficient; and a step of obtaining by the signal processing unit image data using the subtraction signal. ### Claim 18 A control method for an image information obtaining apparatus having a light source, a transducer configured to convert an acoustic into an electrical signal, a memory, and a signal processing unit, wherein the memory stores reference image data which is obtained based on an acoustic wave generated when a phantom, which simulates an object and is located at a position where the object is to be located, is irradiated with light from the light source, the control method comprising: a step of irradiating the object with light from the light source; a step of acquiring by the transducer an object acoustic signal by acquiring an acoustic wave, generated when the object is irradiated with light from the light source; a step of obtaining by the signal processing unit object image data using the object acoustic signal; a step of obtaining by the signal processing unit an intensity of image data corresponding to the acoustic wave generated from a surface of the object, out of the object image data; a step of obtaining by the signal processing unit an intensity of image data corresponding to the acoustic wave generated from a surface of the phantom, out of the reference image data; a step of obtaining by the signal processing unit a correction coefficient based on a result of comparing between the intensity of the image data corresponding to the acoustic wave generated from the surface of the object and the intensity of the image data corresponding to the acoustic wave generated from the surface of the phantom; and a step of obtaining by the signal processing unit subtraction image data between the reference image data and the object image data, which are corrected by using the correction coefficient.