# US 9,434,991 B2 · Method of testing for endometriosis and treatment therefor > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 9,434,991 B2 - Document ID: US9434991B2 - Status: Granted - Kind: B2 - Application number: 13/789,082 - Filed: 2013-03-07 - Published: 2015-12-24 - Granted: 2016-09-06 - Earliest claimed: 2013-03-07 - Assignees: Juneau Biosciences, LLC - Applicants: Kenneth Ward; Rakesh N. Chettier; Hans Albertsen - Inventors: Kenneth Ward; Rakesh N. Chettier; Hans Albertsen - Web page: https://patentgrep.com/patent/US9434991B2 ## CPC - A61K 31/566: having an oxo group in position 17, e.g. estrone - C12Q 1/6883: for diseases caused by alterations of genetic material - C12Q 2600/156: Polymorphic or mutational markers - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - C12Q: MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS (immunoassay G01N33/53); COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES ## Abstract The present invention relates to novel genetic markers associated with endometriosis and risk of developing endometriosis, and methods and materials for determining whether a human subject has endometriosis or is at risk of developing endometriosis and the use of such risk information in selectively administering a treatment that at least partially prevents or compensates for an endometriosis related symptom. ## Claims ### Claim 1 A method of performing an ART comprising: obtaining an egg of a female subject, detecting in the DNA of said subject at least one predetermined gynecological disorder associated biomarker, and performing a fertility treatment wherein at least one of said egg and sperm are handled in vitro. ### Claim 2 (depends on 1) The method of claim 1, wherein said performing a fertility treatment is preceded by the steps of: obtaining clinical data (CD) of said subject, said CD defining the answers to the questions of “menarche after age 14 (Y/N)”, “dysmenorrhea (Y/N)”, and “previous pregnancy (Y/N)”, assigning a raw clinical probability value (RCPV) to said CD, and performing a laparoscopy on said subject, wherein said at least one predetermined gynecological disorder associated biomarker defines the minor allele of at least one biomarker of table 1, and wherein said gynecological disorder defines at least one of existence of endometriosis, predisposition of endometriosis, infertility, and predisposition of infertility. ### Claim 3 (depends on 1) The method of claim 1, wherein said subject defines an endometriosis asymptomatic subject. ### Claim 4 (depends on 1) The method of claim 1, wherein said at least one predetermined gynecological disorder associated biomarker defines the minor allele of at least one biomarker of table 1. ### Claim 5 (depends on 1) The method of claim 1, wherein said method includes administering an OC to said subject. ### Claim 6 A method of performing an ART comprising: obtaining an egg of a female subject, detecting in said subject at least one predetermined gynecological disorder associated biomarker, and performing a fertility treatment on said egg in vitro. ### Claim 7 (depends on 6) The method of claim 6, wherein said performing a fertility treatment is preceded by the steps of: obtaining clinical data (CD) of said subject, said CD defining the answers to the questions of “menarche after age 14 (Y/N)”, “dysmenorrhea (Y/N)”, and “previous pregnancy (Y/N)”, assigning a raw clinical probability value (RCPV) to said CD, and performing a laparoscopy on said subject, wherein said at least one predetermined gynecological disorder associated biomarker defines the minor allele of at least one biomarker of table 1, and wherein said gynecological disorder defines at least one of existence of endometriosis, predisposition of endometriosis, infertility, and predisposition of infertility. ### Claim 8 (depends on 6) The method of claim 6, wherein said subject defines an endometriosis asymptomatic subject. ### Claim 9 (depends on 6) The method of claim 6, wherein said at least one predetermined gynecological disorder associated biomarker defines the minor allele of at least one biomarker of table 1. ### Claim 10 (depends on 6) The method of claim 6, wherein said method includes administering an OC to said subject. ### Claim 11 (depends on 6) The method of claim 6, wherein said at least one predetermined gynecological disorder associated biomarker is located in the DNA of said subject. ### Claim 12 (depends on 6) The method of claim 6, wherein said performing a fertility treatment further defines performing a fertility treatment wherein at least one of said egg and sperm are handled in vitro. ### Claim 13 A method of performing an ART comprising: obtaining an egg of a female subject having at least one predetermined gynecological disorder associated biomarker therein, and performing a fertility treatment on said egg in vitro. ### Claim 14 (depends on 13) The method of claim 13, wherein said performing a fertility treatment is preceded by the steps of: detecting in the DNA of said subject at least one predetermined gynecological disorder associated biomarker, obtaining clinical data (CD) of said subject, said CD defining the answers to the questions of “menarche after age 14 (Y/N)”, “dysmenorrhea (Y/N)”, and “previous pregnancy (Y/N)”, assigning a raw clinical probability value (RCPV) to said CD, and performing a laparoscopy on said subject, wherein said at least one predetermined gynecological disorder associated biomarker defines the minor allele of at least one biomarker of table 1, and wherein said gynecological disorder defines at least one of existence of endometriosis, predisposition of endometriosis, infertility, and predisposition of infertility. ### Claim 15 (depends on 13) The method of claim 13, wherein said subject defines an endometriosis asymptomatic subject. ### Claim 16 (depends on 13) The method of claim 13, wherein said at least one predetermined gynecological disorder associated biomarker defines the minor allele of at least one biomarker of table 1. ### Claim 17 (depends on 13) The method of claim 13, wherein said method includes administering an OC to said subject. ### Claim 18 (depends on 13) The method of claim 13, wherein said at least one predetermined gynecological disorder associated biomarker is located in the DNA of said subject. ### Claim 19 (depends on 13) The method of claim 13, wherein said performing a fertility treatment on said egg in vitro further defines performing a fertility treatment wherein at least one of said egg and sperm are handled in vitro. ### Claim 20 (depends on 13) The method of claim 13, wherein said performing a fertility treatment is preceded by the step of detecting in the DNA of said subject at least one predetermined gynecological disorder associated biomarker.