# US 9,434,775 B2 · Gene overexpressed in cancer

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 9,434,775 B2
- Document ID: US9434775B2
- Status: Granted
- Kind: B2
- Application number: 12/384,165
- Filed: 2009-04-01
- Published: 2009-09-10
- Granted: 2016-09-06
- Earliest claimed: 2003-08-08
- Assignees: Hiroyuki Aburatani; Perseus Proteomics Inc.; Chugai Seiyaku Kabushiki Kaisha
- Applicants: Hiroyuki Aburatani; Yoshitaka Hippo; Hirokazu Taniguchi; Yong xin Chen; Shumpei Ishikawa; Shin-ichi Fukumoto; Takahiro Shimamura; Naoka Kamimura; Ying qiu Guo; Shogo Yamamoto; Yukio Ito; Hirotaka Ito; Toshihiko Ohtomo
- Inventors: Hiroyuki Aburatani; Yoshitaka Hippo; Hirokazu Taniguchi; Yong xin Chen; Shumpei Ishikawa; Shin-ichi Fukumoto; Takahiro Shimamura; Naoka Kamimura; Ying qiu Guo; Shogo Yamamoto; Yukio Ito; Hirotaka Ito; Toshihiko Ohtomo
- Web page: https://patentgrep.com/patent/US9434775B2

## CPC

- C07K 14/47: from mammals
- A61P 35/00: Antineoplastic agents
- C12Q 1/6886: for cancer (immunoassay for cancer G01N33/575)
- C12Q 2600/136: Screening for pharmacological compounds
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C12Q: MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS (immunoassay G01N33/53); COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES

## Abstract

Disclosed are a protein encoded by a gene having a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a fragment thereof, an antibody recognizing the protein or antigen-binding fragment thereof, and a polynucleotide having a sequence comprising at least 12 consecutive nucleotides of a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a nucleotide sequence complementary thereto. The gene and the protein of the invention is useful for diagnosing and treating cancer.

## Claims

### Claim 1

A cDNA having the nucleotide sequence of SEQ ID NO: 15 or the complete complement thereof.

### Claim 2 (depends on 1)

A composition for diagnosing or treating liver cancer comprising the polynucleotide according to claim 1.

### Claim 3 (depends on 1)

A vector comprising the polynucleotide according to claim 1.

### Claim 4 (depends on 3)

A cell comprising the vector according to claim 3.