# US 9,434,742 B1 · Thieno- and pyrrolopyrimidine analogues as anticancer agents and methods of use thereof

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 9,434,742 B1
- Document ID: US9434742B1
- Status: Granted
- Kind: B1
- Application number: 14/634,940
- Filed: 2015-03-02
- Published: 2016-09-08
- Granted: 2016-09-06
- Earliest claimed: 2015-03-02
- Assignees: University of Maryland, Baltimore County
- Applicants: University of Maryland, Baltimore County
- Inventors: Katherine L. Radtke; Kartik Temburnikar
- Web page: https://patentgrep.com/patent/US9434742B1

## CPC

- A61K 31/519: ortho- or peri-condensed with heterocyclic rings
- C07D 487/04: Ortho-condensed systems
- C07D 495/04: Ortho-condensed systems
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)

## Abstract

The present invention provides for the design and synthesis of halogenated thieno- and pyrrolopyrimidine compounds that exhibit cancer proliferation inhibitory activity and the use thereof for cancer treatment.

## Claims

### Claim 1

A method of inducing apoptosis and/or inhibiting the growth of cancer cells, the method comprising administering to breast, colon, renal, melanoma and leukemia cancer cells an effective amount of a halogenated thienopyrimidine compound having the following formula:
wherein X is S and Y is H or Br, wherein the effective amount induces apoptosis and/or inhibits the growth of the cancer cells.

### Claim 2 (depends on 1)

The method of claim 1, wherein the halogenated thienopyrimidine compound reduces tumor burden without inhibiting kinases.

### Claim 3

A method of inducing apoptosis and/or inhibiting the growth of cancer cells, the method comprising administering to breast, colon, renal, melanoma and leukemia cancer cells an effective amount of a halogenated pyrrolopyrimidine compound having the following formula:
wherein X is NH and Y is H or I, wherein the effective amount induces apoptosis and/or inhibits the growth of the cancer cells.

### Claim 4 (depends on 3)

The method of claim 3, wherein the halogenated pyrrolopyrimidine compound reduces tumor burden without inhibiting kinases.