# US 9,434,694 B2 · Method for preparation of medetomidine with chloroacetone

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- Number: US 9,434,694 B2
- Document ID: US9434694B2
- Status: Granted
- Kind: B2
- Application number: 14/813,681
- Filed: 2015-07-30
- Published: 2015-11-26
- Granted: 2016-09-06
- Earliest claimed: 2012-06-28
- Assignees: Lonza Ltd.
- Applicants: Lonza Ltd
- Inventors: Florencio Zaragoza Doerwald; Anna Kulesza; Stephan Elzner; Robert Bujok; Zbigniew Wrobel; Krzysztof Wojciechowski
- Web page: https://patentgrep.com/patent/US9434694B2

## CPC

- C07D 233/58: with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
- C07D 233/56: with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D 263/16: with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)

## Abstract

The invention discloses a method for the preparation of medetomidine starting from 1-bromo 2,3-dimethylbenzene and chloroacetone.

## Claims

### Claim 1

A compound of formula (XXIII),
wherein
R2 is 4-tolyl, phenyl, 4-acetamidophenyl, methyl or trifluoromethyl.

### Claim 2 (depends on 1)

The compound according to claim 1, wherein R2 is 4-tolyl.