# US 9,434,687 B2 · Detection of synthetic cannabinoids

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- Number: US 9,434,687 B2
- Document ID: US9434687B2
- Status: Granted
- Kind: B2
- Application number: 13/585,646
- Filed: 2012-08-14
- Published: 2013-03-14
- Granted: 2016-09-06
- Earliest claimed: 2011-02-14
- Assignees: Randox Laboratories Limited
- Applicants: Elouard Benchikh; Stephen Peter FitzGerald; Paul John Innocenzi; Philip Andrew Lowry; Ivan Robert McConnell
- Inventors: Elouard Benchikh; Stephen Peter FitzGerald; Paul John Innocenzi; Philip Andrew Lowry; Ivan Robert McConnell
- Web page: https://patentgrep.com/patent/US9434687B2

## CPC

- C07D 209/12: Radicals substituted by oxygen atoms
- C07K 16/44: against material not provided for elsewhere {, e.g. haptens, metals, DNA, RNA, amino acids}
- C07K 17/14: Peptides being immobilised on, or in, an inorganic carrier
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)

## Abstract

The invention describes methods and kits for detecting and determining current and future synthetic cannabinoids from the JWH and CP families. Unique antibodies derived from novel immunogens enable said methods and kits.

## Claims

### Claim 1

An antibody that binds to structure:
wherein
R4,1 is a C4 or C5, substituted or unsubstituted, saturated or unsaturated, hydrocarbon chain; and,
Y is substituted or unsubstituted naphthyl or substituted phenyl; and,
wherein the antibody has a cross-reactivity presented as B/B0% of ≦15% (standardised with JWH-018 and using tracer ESC5913,
wherein JWH-018 is
wherein ESC5913 is
and
wherein HRP is Horse Radish Peroxidase)
against each one of the cross-reactants selected from the group consisting of JWH-018, JWH-018 (N-(3-methylbutyl) isomer, JWH-073, JWH-073 4-methylnaphthyl analogue, JWH-022, JWH-081, JWH-081 5-methoxynaphthyl isomer, JWH-122, JWH-122 6-methylnaphthyl isomer, JWH-122 7-methylnaphthyl isomer, JWH-182, JWH-210, JWH-398, JWH-398 5-chloronaphthyl isomer, AM-694, AM-2201, and AM-2201 N-(4-fluoropentyl) isomer,
at a cross-reactant concentration of 100 ng/ml,
wherein B0 is absorbance at 450 nm at zero ng/ml standard concentration, and
wherein B is absorbance at 450 nm at predetermined standard concentrations.