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US 9,434,660 B2Granted
Methods for preparation of lycopenes from C15-wittig salts and methods for purification of high all-E containing and high 6Z containing C15-wittig salts
AssigneeAllied Biotech, Inc.
InventorsHaw-Shyi Chiu, Po-Wei Lin
Life of this patent
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Abstract
The present invention relates to methods for preparation of lycopenes, especially to lycopenes with high all-E contents or high 6Z contents from C15-Wittig slats mixtures.(with high all-E-contents and high 6Z-contents, respectively). C15-Wittig slats mixtures are purified and 6Z-C15-Wittig salts are extracted from the mixtures. The extracted 6Z-C15-Wittig salts are, used in the synthesis of lycopenes with high 6Z contents and the residues are used in the synthesis of lycopenes with high All-E contents.
Claims12
A method for synthesis of lycopenes which comprises
- obtaining a C15-Wittig salt cis/trans mixture;
- purifying the C15-Wittig salt cis/trans mixture to remove solvents;
- adding an aprotic solvent comprising acetone to the C15 Wittig salt cis/trans mixture to extract 6Z-C15-Wittig salts from the mixture;
- removing the 6Z-C15-Wittig salts from the mixture to obtain residues;
- purifying the obtained residues to obtain C15-Wittig salts with high all-E contents;
- and
- reacting said obtained C15-Wittig salts with a C10-dialdehyde in a double-Wittig reaction in the presence of a base reactant to obtain said lycopenes.
4 more elements
A method for synthesis of lycopenes, comprising:
- obtaining a C15-Wittig salt cis/trans mixture;
- purifying the C15-Wittig salt cis/trans mixture to remove solvents;
- adding an aprotic solvent comprising acetone to the C15 Wittig salt cis/trans mixture to extract 6Z-C15-Wittig salts from the mixture;
- and
- purifying the 6Z-C15-Wittig salts to obtain C15-Wittig salts;
- and
- reacting said obtained C15-Wittig salts with a C10-dialdehyde in a double-Wittig reaction in the present of a base reactant to obtain said lycopenes.
4 more elements
Dependencies are inferred from the claim text.